CAPILLARY ELECTROPHORESIS QUANTITATION OF L-L-FOLINIC ACID IN THE PRESENCE OF ITS INACTIVE D-L-FORM

被引：13

作者：

CELLAI, L

DESIDERIO, C

FILIPPETTI, R

FANALI, S

机构：

[1] CNR,IST CROMATOG,CP 10,I-00016 MONTEROTONDO,ITALY

[2] CNR,IST STRUTTURIST CHIM,I-00016 MONTEROTONDO,ITALY

来源：

ELECTROPHORESIS | 1993年 / 14卷 / 08期

关键词：

D O I：

10.1002/elps.11501401129

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The diastereomers d-L and l-L-folinic acid were separated by capillary electrophoresis, using heptakis (2,3-di-0-methyl)-beta-cyclodextrin as a chiral active component in the background electrolyte. The method proved suitable for the quantitation of these compounds in one commercial pharmaceutical preparation.

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页码：823 / 825

页数：3

相关论文

共 19 条

[1]

ARIJENS EJ, 1987, J CHIM PHARM THER, V42, P361

[2] DIRECT LIQUID-CHROMATOGRAPHIC SEPARATION OF RACEMATES WITH AN ALPHA-CYCLODEXTRIN BONDED PHASE [J].

ARMSTRONG, DW ;

YANG, XF ;

HAN, SM ;

MENGES, RA .

ANALYTICAL CHEMISTRY, 1987, 59 (21) :2594-2596

[3] CHIRAL SEPARATION OF LEUCOVORIN WITH BOVINE SERUM-ALBUMIN USING AFFINITY CAPILLARY ELECTROPHORESIS [J].

BARKER, GE ;

RUSSO, P ;

HARTWICK, RA .

ANALYTICAL CHEMISTRY, 1992, 64 (23) :3024-3028

[4]

Blakley R. L., 1969, FRONT BIOL

[5] CHROMATOGRAPHIC RESOLUTION OF CHIRAL DRUGS ON POLYAMIDES AND CELLULOSE TRIACETATE [J].

BLASCHKE, G .

JOURNAL OF LIQUID CHROMATOGRAPHY, 1986, 9 (2-3) :341-368

[6] IMPROVED ACYLATION RATES WITHIN CYCLODEXTRIN COMPLEXES FROM FLEXIBLE CAPPING OF THE CYCLODEXTRIN AND FROM ADJUSTMENT OF THE SUBSTRATE GEOMETRY [J].

BRESLOW, R ;

CZARNIECKI, MF ;

EMERT, J ;

HAMAGUCHI, H .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1980, 102 (02) :762-770

[7] CRYSTAL AND MOLECULAR-STRUCTURE OF A 2,6-TETRADECA-O-METHYL-BETA-CYCLODEXTRIN-ADAMANTANOL 1-1 INCLUSION COMPLEX [J].

CZUGLER, M ;

ECKLE, E ;

STEZOWSKI, JJ .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1981, (24) :1291-1292

[8] RESOLUTION OF SOME CHIRAL MANDELIC-ACID DERIVATIVES INTO ENANTIOMERS BY REVERSED-PHASE HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY VIA ALPHA-CYCLODEXTRIN AND BETA-CYCLODEXTRIN INCLUSION COMPLEXES [J].

DEBOWSKI, J ;

JURCZAK, J ;

SYBILSKA, D .

JOURNAL OF CHROMATOGRAPHY, 1983, 282 (DEC) :83-88

[9] USE OF CYCLODEXTRINS FOR THE ENANTIOSELECTIVE SEPARATION OF ERGOT ALKALOIDS BY CAPILLARY ZONE ELECTROPHORESIS [J].

FANALI, S ;

FLIEGER, M ;

STEINEROVA, N ;

NARDI, A .

ELECTROPHORESIS, 1992, 13 (1-2) :39-43

[10] SEPARATION OF OPTICAL ISOMERS BY CAPILLARY ZONE ELECTROPHORESIS BASED ON HOST GUEST COMPLEXATION WITH CYCLODEXTRINS [J].

FANALI, S .

JOURNAL OF CHROMATOGRAPHY, 1989, 474 (02) :441-446