A HEMEOBOX GENE ESSENTIAL FOR ZEBRAFISH NOTOCHORD DEVELOPMENT

被引：405

作者：

TALBOT, WS

TREVARROW, B

HALPERN, ME

MELBY, AE

FARR, G

POSTLETHWAIT, JH

JOWETT, T

KIMMEL, CB

KIMELMAN, D

机构：

[1] UNIV WASHINGTON,DEPT BIOCHEM,SEATTLE,WA 98195

[2] UNIV OREGON,INST NEUROSCI,EUGENE,OR 97403

[3] UNIV NEWCASTLE UPON TYNE,DEPT BIOCHEM & GENET,NEWCASTLE TYNE NE2 4HH,TYNE & WEAR,ENGLAND

来源：

NATURE | 1995年 / 378卷 / 6553期

基金：

英国惠康基金;

关键词：

D O I：

10.1038/378150a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The notochord is a midline mesodermal structure with an essential patterning function in all vertebrate embryos. Zebrafish floating head (flh) mutants lack a notochord, but develop with prechordal plate and other mesodermal derivatives, indicating that flh functions specifically in notochord development. We show that floating head Is the zebrafish homologue of Xnot, a homeobox gene expressed In the amphibian organizer and notochord. We propose that flh regulates notochord precursor cell fate.

引用

页码：150 / 157

页数：8

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