Adipose-Derived Stem Cells in Crohn's Rectovaginal Fistula

被引：52

作者：

Garcia-Olmo, D. ^{[1
,2
,3
]}

Herreros, D. ^{[1
]}

De-La-Quintana, P. ^{[1
]}

Guadalajara, H. ^{[1
]}

Trebol, J. ^{[1
]}

Georgiev-Hristov, T. ^{[1
]}

Garcia-Arranz, M. ^{[2
,3
]}

机构：

[1] La Paz Univ Hosp IdiPAZ, Dept Surg, Madrid 28046, Spain

[2] La Paz Univ Hosp IdiAZ, Fdn Biomed Res, Cell Therapy Lab, Madrid 28046, Spain

[3] Autonomous Univ Madrid, Sch Med, Madrid 28029, Spain

来源：

CASE REPORTS IN MEDICINE | 2010年 / 2010卷

关键词：

D O I：

10.1155/2010/961758

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Therapeutic options for recto-vaginal fistula in the setting of Crohn's disease are limited and many data are available in the literature. The manuscript describes the history of a patient who has been the pioneer of our Clinical Trials in treating this disease in fistulizing Crohn's disease environment. We believe it is the first time that a patient with this disease has been treated by adiposederived stem cells in allogeneic form. The conclusion of our study with Mary is that the use of mesenchymal stem cells derived from adipose tissue is secure, either in autologous or allogeneic form. Furthermore, we have proved that if we use multi-dose and multiple applications on a patient, it does not produce any adverse effect, which confirms us the safety of using these cells in patients at least in the fistulizing Crohn's disease environment.

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