BIOCHEMICAL AND GENETIC-STUDIES ON RABBIT HEMOGLOBIN .2. ELECTROPHORETIC POLYMORPHISM OF THE ALPHA-CHAIN

被引：14

作者：

FERRAND, N

机构：

[1] Instituto de Zoologia, Faculdade de Ciências, Universidade do Porto, Porto

来源：

BIOCHEMICAL GENETICS | 1990年 / 28卷 / 3-4期

关键词：

α-chain; electrophoretic polymorphism; hemoglobin; neutral amino acids; rabbit;

D O I：

10.1007/BF00561331

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A genetic polymorphism of rabbit (Oryctolagus cuniculus) hemoglobin α chain is demonstrated by means of acid starch gel electrophoresis. The polymorphism is not detected by isoelectric focusing and may be based upon neutral for neutral amino acid substitutions in accordance with previous findings by means of amino acid sequencing. Segregation analysis was performed on 15 matings with 49 offspring and confirmed the initial genetic hypothesis of three common codominant alleles at an autosomal locus. The calculated gene frequencies in a random sample of 86 unrelated individuals are HBA*1=0.73, HBA*2=0.22, and HBA*3=0.05. © 1990 Plenum Publishing Corporation.

引用

页码：117 / 122

页数：6

共 13 条

[1] PARAFFIN OIL PROTECTED HIGH-RESOLUTION HYBRID ISOELECTRIC-FOCUSING FOR THE DEMONSTRATION OF SUBSTITUTIONS OF NEUTRAL AMINO-ACIDS IN DENATURED PROTEINS - THE CASE OF 4 HUMAN TRANSTHYRETIN (PREALBUMIN) VARIANTS ASSOCIATED WITH FAMILIAL AMYLOIDOTIC POLYNEUROPATHY [J].