COMPARATIVE INVITRO ACTIVITY OF AZITHROMYCIN AND ERYTHROMYCIN AGAINST GRAM-POSITIVE COCCI, HAEMOPHILUS-INFLUENZAE AND ANAEROBES

被引:60
作者
MASKELL, JP
SEFTON, AM
WILLIAMS, JD
机构
[1] Department of Medical Microbiology, The London Hospital Medical College, London
关键词
D O I
10.1093/jac/25.suppl_A.19
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
The in-vitro activities of azithromycin and erythromycin were compared against 689 clinical isolates, including Gram-positive cocci, Haemophilus influenzae, and anaerobes. Of the 100 methicillin-susceptible isolates of Staphylococcus aureus tested, 77% were susceptible to 1 mg/l azithromycin and 0.5 mg/l erythromycin, whereas 22% were resistant to 32 mg/l of both compounds. All methicillin-resistant S. aureus isolates were highly resistant to both macrolides (MIC > 64 mg/l). Coagulase-negative staphylococci showed a wide range of susceptibilities to both compounds; MIC90 values for azithromycin and erythromycin for all isolates were 0.5 and 0.25 mg/l, respectively. With the exception of enterococci, both macrolides showed similar activity against streptococci; MIC90, values for both group A and group B streptococci were 0.03 and 0.06 mg/l for erythromycin and azithromycin, respectively. Azithromycin was less active than erythromycin against enterococci, with mode MICs of 4.0 and 1.0 mg/l, respectively; about 20% of isolates were highly resistant to both compounds. Azithromycin was substantially more active than erythromycin against H. influenzae; 41% of isolates were inhibited by 0.5 mg/l azithromycin and all isolates were inhibited by 2 mg/l. The MIC90, for erythromycin was 8 mg/l; 36% of isolates required concentrations of ≥ 4 mg/l for inhibition. The anaerobic bacteria tested showed similar susceptibility to both azithromycin and erythromycin. © 1990 The British Society for Antimicrobial Chemotherapy.
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页码:19 / 24
页数:6
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