COMPARATIVE ANTIARRHYTHMIC AND ANTIISCHEMIC ACTIVITY OF SOME FLAVONES IN THE GUINEA-PIG AND RAT

被引：19

作者：

OCCHIUTO, F ^{[1
]}

BUSA, G ^{[1
]}

RAGUSA, S ^{[1
]}

DEPASQUALE, A ^{[1
]}

机构：

[1] UNIV CAGLIARI,INST PHARMACOL & EXPTL THERAPEUT,I-09100 CAGLIARI,ITALY

来源：

PHYTOTHERAPY RESEARCH | 1991年 / 5卷 / 01期

关键词：

FLAVONES; ISOLATED RAT HEART; CORONARY LIGATION; CORONARY SPASM; REPERFUSION; VENTRICULAR ARRHYTHMIA; MYOCARDIAL ISCHEMIC AREA;

D O I：

10.1002/ptr.2650050104

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A comparative study of 16 flavones was carried out using 4 experimental models: 1, hyperkinetic ventricular arrhythmias induced by reperfusion in rat isolated heart; 2, arrhythmias following coronary artery ligation-reperfusion in anaesthetized guinea-pig; 3, pytressine arrhythmias by coronary spasm in anaesthetized guinea-pig; and 4, anti-ischaemic activity using an ex vivo perfusion heart technique after coronary occlusion in guinea-pig. The structure effect relationships of flavone, 3-hydroxyflavone, 6-hydroxyflavone, 7-hydroxyflavone, 6,7-dihydroxyflavone, 7,8-dihydroxyflavone, apigenin, apiin, diosmin, 5-hydroxyflavone, luteolin, luteolin glycoside, orientin, pratol, rhoifolin, vitexin, tested as antiarrhythmic and anti-ischaemic agents were compared to lidocaine and verapamil at equimolar doses. The results obtained demonstrated that most of these compounds exerted a protective effect against coronary-spasm and coronary-ligation induced ischaemic crisis, and against the ischaemic and the post-ischaemic arrhythmias. The potencies were found to be structurally dependent for the flavones tested.

引用

页码：9 / 14

页数：6

共 13 条

[1] EFFECTS OF ISCHEMIA AND REPERFUSION ON CALCIUM EXCHANGE AND MECHANICAL FUNCTION IN ISOLATED RABBIT MYOCARDIUM [J].

BOURDILLON, PDV ;

POOLEWILSON, PA .

CARDIOVASCULAR RESEARCH, 1981, 15 (03) :121-130

[2]

CIRCOSTA C, 1984, J ETHNOPHARMACOL, V2, P359

[3] CORONARY-ARTERY LIGATION IN ANESTHETIZED RATS AS A METHOD FOR THE PRODUCTION OF EXPERIMENTAL DYSRHYTHMIAS AND FOR THE DETERMINATION OF INFARCT SIZE [J].

CLARK, C ;

FOREMAN, MI ;

KANE, KA ;

MCDONALD, FM ;

PARRATT, JR .

JOURNAL OF PHARMACOLOGICAL METHODS, 1980, 3 (04) :357-368

[4]

COSTA R, 1986, Plantes Medicinales et Phytotherapie, V20, P115

[5]

DENUNNO R, 1947, RIV CLIN MED, V47, P506

[6]

GABOR M, 1986, PLANT FLAVONOIDS BIO, P471

[7]

HARRIGTN S, 1985, COMPUTER GRAPHICS PR

[8] CORONARY-ARTERY LIGATION, EARLY ARRHYTHMIAS, AND DETERMINATION OF THE ISCHEMIC AREA IN CONSCIOUS RATS [J].

LEPRAN, I ;

KOLTAI, M ;

SIEGMUND, W ;

SZEKERES, L .

JOURNAL OF PHARMACOLOGICAL METHODS, 1983, 9 (03) :219-230

[9]

LOWN B, 1975, CIRCULATION, V189, P51

[10]

NISHINO H, 1984, GANN, V74, P311

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