FUNCTIONAL SIMILARITIES BETWEEN RETROVIRUSES AND THE IS3 FAMILY OF BACTERIAL INSERTION SEQUENCES

被引：183

作者：

FAYET, O

RAMOND, P

POLARD, P

PRERE, MF

CHANDLER, M

机构：

[1] CNRS,CTR RECH BIOCHIM & GENET,118 ROUTE NARBONNE,F-31062 TOULOUSE,FRANCE

[2] SANOFI ELF BIO RECHE,LABEGE INNOPOLE,F-31328 LABEGE,FRANCE

来源：

MOLECULAR MICROBIOLOGY | 1990年 / 4卷 / 10期

关键词：

D O I：

10.1111/j.1365-2958.1990.tb00555.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Members of the IS3 family of insertion sequences are found in a wide range of bacteria. At least 10 members of this family carry two major open reading frames: a small upstream frame (0 phase), and a longer downstream frame In the –1 phase. The downstream frame shows significant similarity at the amino acid level. A highly conserved region of this frame also exhibits notable similarity with a region of the Integrase (endonuclease) domain of retroviruses. Although the overall transposition mechanism of the insertion sequence and retroviral elements is certainly different, the two groups may share additional common features, including a −1 frameshift resulting in the production of a fusion protein. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：1771 / 1777

页数：7

共 47 条

[1] THE INTEGRASE FAMILY OF SITE-SPECIFIC RECOMBINASES - REGIONAL SIMILARITIES AND GLOBAL DIVERSITY [J].