GENERATION OF SUPEROXIDE ANION BY BRAIN ENDOTHELIAL-CELL XANTHINE-OXIDASE

被引：87

作者：

TERADA, LS

WILLINGHAM, IR

ROSANDICH, ME

LEFF, JA

KINDT, GW

REPINE, JE

机构：

[1] UNIV COLORADO, HLTH SCI CTR, WEBB WARING LUNG INST, DENVER, CO 80262 USA

[2] UNIV COLORADO, HLTH SCI CTR, DEPT MED, DENVER, CO 80262 USA

[3] UNIV COLORADO, HLTH SCI CTR, DEPT NEUROSURG, DENVER, CO 80262 USA

来源：

JOURNAL OF CELLULAR PHYSIOLOGY | 1991年 / 148卷 / 02期

关键词：

D O I：

10.1002/jcp.1041480202

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Bovine brain endothelial cells (EC) that were isolated and propagated in pure culture had increased (> 20-fold) levels of xanthine oxidase and xanthine dehydrogenase activity compared to whole brain homogenate. Brain EC also released superoxide anion (O2-) into the extracellular medium. Treatment of EC with tungsten decreased (P < 0.05) both XO activity and O2- release. XO appears to be highly concentrated in cerebral vascular endothelium and may be an important source of O2-.

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页码：191 / 196

页数：6

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