ENDOTHELIN PRODUCTION BY AMNION AND ITS REGULATION BY CYTOKINES

被引：42

作者：

MITCHELL, MD

LUNDINSCHILLER, S

EDWIN, SS

机构：

[1] Department of Obstetrics and Gynecology, University of Utah, Salt Lake City, UT

来源：

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY | 1991年 / 165卷 / 01期

关键词：

ENDOTHELIN; AMNION; CYTOKINE; AVASCULAR;

D O I：

10.1016/0002-9378(91)90238-M

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Cells derived from human amnion, an avascular tissue, produced significant amounts of endothelin 1 and 2, although the rate of biosynthesis was approximately one tenth of that of human umbilical vein endothelial cells. Endothelin 1 and 2 was not produced in measurable amounts by cells derived from chorion laeve or decidua. Production of endothelin 1 and 2 by amnion cells was increased by treatment with the cytokines interleukin-1-beta, tumor necrosis factor, and interleukin-6. The biosynthesis of endothelin 1 and 2 by an avascular tissue is suggestive of a wider role for endothelins than has been recognized.

引用

页码：120 / 124

页数：5

共 19 条

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