EXON-INTRON ORGANIZATION OF THE GENE ENCODING THE MOUSE EPITHELIN GRANULIN PRECURSOR (ACROGRANIN)

被引：35

作者：

BABA, T ^{[1
]}

NEMOTO, H ^{[1
]}

WATANABE, K ^{[1
]}

ARAI, Y ^{[1
]}

GERTON, GL ^{[1
]}

机构：

[1] UNIV PENN,SCH MED,DEPT OBSTET & GYNECOL,PHILADELPHIA,PA 19104

来源：

FEBS LETTERS | 1993年 / 322卷 / 02期

关键词：

EPITHELIN; GRANULIN; ACROGRANIN; GENOMIC DNA; GENE ORGANIZATION; GROWTH-MODULATING PEPTIDE;

D O I：

10.1016/0014-5793(93)81544-A

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mouse genomic clones encoding the epithelin/granulin gene and its 5'- and 3'-flanking regions have been isolated and sequenced. This gene was found to be a single-copy gene, and contained 13 exons interrupted by 12 introns. Eight out of the 12 introns are classified as phase 0, and are located within the central part of each of the tandem repeats in the amino acid sequence of the epithelin/granulin precursor. The first intron is unique because of the interruption of the 5'-untranslated region and its fairly large size (approximately 2.4 kbp). Consensus sequences for several of the potential regulatory elements are present in the 5'-flanking sequence, including a common CCAAT sequence.

引用

页码：89 / 94

页数：6

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