INCREASES OF GLIAL FIBRILLARY ACIDIC PROTEIN IN THE AGING FEMALE MOUSE-BRAIN

被引:112
作者
KOHAMA, SG
GOSS, JR
FINCH, CE
MCNEILL, TH
机构
[1] UNIV SO CALIF,ETHEL PERCY ANDRUS GERONTOL CTR,LOS ANGELES,CA 90089
[2] UNIV SO CALIF,DEPT SCI BIOL,LOS ANGELES,CA 90089
关键词
GFAP; BRAIN; IN SITU HYBRIDIZATION; IMMUNOCYTOCHEMISTRY; AGING; MOUSE; WHITE MATTER; GRAY MATTER;
D O I
10.1016/0197-4580(95)80008-F
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Age-related increases of the astrocyte marker, glial fibrillary acidic protein (GFAP), were further resolved by in situ hybridization and immunocytochemistry in female C57BL/6J mice. The age groups represented the major stages of reproductive aging: young (5 months), middle-age (18 months), and old (23 and 26 months). GFAP mRNA and protein showed generalized increases in old mice. Major white fiber tracts, such as the corpus callosum, fimbria, stria terminalis, and optic tract, showed increased GFAP immunostaining and mRNA. Gray matter showed robust greater than or equal to twofold increases in GFAP mRNA with age, especially in the thalamus and hypothalamus, areas that expressed little GFAP in the young. These generalized age-related increases of GFAP in many brain regions imply the existence of a widespread stimulus for increased activity of astrocytes during aging.
引用
收藏
页码:59 / 67
页数:9
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