PHOTOCHEMICAL STABILITY OF BIOLOGICALLY-ACTIVE COMPOUNDS .5. PHOTOCHEMICAL DEGRADATION OF PRIMAQUINE IN AN AQUEOUS-MEDIUM

被引：21

作者：

KRISTENSEN, S

GRISLINGAAS, AL

GREENHILL, JV

SKJETNE, T

KARLSEN, J

TONNESEN, HH

机构：

[1] UNIV FLORIDA,DEPT CHEM,GAINESVILLE,FL 32611

[2] SINTEF UNIMED,CTR MR,N-7034 TRONDHEIM,NORWAY

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1993年 / 100卷 / 1-3期

关键词：

PRIMAQUINE; PHOTOCHEMICAL STABILITY; ANTIMALARIAL; AMINOQUINOLINE;

D O I：

10.1016/0378-5173(93)90070-V

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Quinoline antimalarials are photochemically unstable. Several of these drugs cause toxic reactions which may be ascribed to the Photochemical degradation of the substances. The effect of light of wavelengths 320-600 nm on the aminoquinoline primaquine in aqueous solution was investigated. The main photochemical degradation products were isolated by means of preparative TLC. The samples were identified by mass spectrometry (EI, CI and high-resolution), H-1-NMR spectroscopy and GC/MS.

引用

页码：15 / 23

页数：9

共 18 条

[1] IDENTIFICATION OF 6-METHOXY 8-AMINOQUINOLINE AS A METABOLITE OF PRIMAQUINE IN MAN [J].