BIOCATALYTIC APPROACH TO ENANTIOMERICALLY PURE BETA-AMINO ACIDS

被引：95

作者：

SOLOSHONOK, VA ^{[1
]}

FOKINA, NA ^{[1
]}

RYBAKOVA, AV ^{[1
]}

SHISHKINA, IP ^{[1
]}

GALUSHKO, SV ^{[1
]}

SOROCHINSKY, AE ^{[1
]}

KUKHAR, VP ^{[1
]}

SAVCHENKO, MV ^{[1
]}

SVEDAS, VK ^{[1
]}

机构：

[1] MOSCOW MV LOMONOSOV STATE UNIV, AN BELOZERSKY INST PHYS CHEM BIOL, MOSCOW 119899, RUSSIA

来源：

TETRAHEDRON-ASYMMETRY | 1995年 / 6卷 / 07期

关键词：

D O I：

10.1016/0957-4166(95)00204-3

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

beta-Aryl-beta-amino acids were prepared in good chemical yield and high enantiomeric purity (> 95% eel via penicillin acylase-catalyzed hydrolysis of the corresponding N-phenylacetyl derivatives. The (R)-enantiomers were the fast-reacting isomers in all cases studied. The biocatalytic procedure described employs very simple set or reactions using inexpensive commercially available chemicals and enzyme, and could be easily scaled up.

引用

页码：1601 / 1610

页数：10

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