INHIBITION BY MN2+ OF CITRATE SUPPORTED PROGESTERONE BIOSYNTHESIS IN MITOCHONDRIAL FRACTIONS OF HUMAN TERM PLACENTAE

被引：17

作者：

BOGUSLAWSKI, W ^{[1
]}

KLIMEK, J ^{[1
]}

TIALOWSKA, B ^{[1
]}

ZELEWSKI, L ^{[1
]}

机构：

[1] MED SCH GDANSK, DEPT BIOCHEM, 80-210 GDANSK, POLAND

来源：

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY | 1976年 / 7卷 / 01期

关键词：

D O I：

10.1016/0022-4731(76)90162-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mitochondrial fraction prepared from human term placentae were incubated with [14C]-cholesterol in the presence of citrate, cis-aconitate or isocitrate. A stimulatory effect of these metabolites on cholesterol to progesterone conversion was found. In contrast to the other metabolites tested, citrate supported progesterone biosynthesis was inhibited by Mn2+. This effect occurred in intact mitochondria only and was accompanied by a decreased citrate consumption.

引用

页码：39 / 44

页数：6

共 19 条

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