PEMOLINE-ASSOCIATED HEPATIC-INJURY

被引：56

作者：

NEHRA, A

MULLICK, F

ISHAK, KG

ZIMMERMAN, HJ

机构：

[1] ARMED FORCES INST PATHOL,DEPT HEPAT,WASHINGTON,DC 20306

[2] VET ADM MED CTR,WASHINGTON,DC 20422

[3] AMER REGISTRY PATHOL,WASHINGTON,DC

[4] GEORGE WASHINGTON UNIV,MED CTR,WASHINGTON,DC 20037

来源：

GASTROENTEROLOGY | 1990年 / 99卷 / 05期

关键词：

D O I：

10.1016/0016-5085(90)91186-A

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Among 100 cases of hepatic injury attributed to the administration of pemoline, 43 had sufficient accompanying information to permit analysis. All but two patients were < 20 years old, and 80% were < 12 years old. Males predominated the study. Injury appeared as early as 1 week or as late as > 1 year of taking the drug. The injury was uniformly hepatocellular as judged by the high values for aminotransferases and by death in massive necrosis in one patient. Mechanism was judged to be idiosyncratic, and the idiosyncrasy was probably metabolic rather than immunologic. © 1990.

引用

页码：1517 / 1519

页数：3