DRUG-TREATMENT OF ALZHEIMERS-DISEASE

被引：19

作者：

COOPER, JK

机构：

来源：

ARCHIVES OF INTERNAL MEDICINE | 1991年 / 151卷 / 02期

关键词：

D O I：

10.1001/archinte.151.2.245

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Drugs may be part of the treatment for Alzheimer's disease. Drug treatment can be divided into two categories: treatment to improve cognitive function and treatment to improve abnormal behaviors. There are at least 16 new drugs undergoing evaluation that may improve cognitive function. Some of these drugs are intended to augment acetylcholine neurotransmitter function. Others are nootropics that affect neuron metabolism with little effect elsewhere. A third major category is drugs that affect brain vasculature. A miscellaneous group includes drugs aimed at modifying other defects found in Alzheimer's disease. Drugs to affect behavior have been available for some time. These include neuroleptics, anxiolytics, and antirage drugs. Use of all these drugs has been controversial. Recent federal legislation and guidelines affect their use in nursing homes. Specific indications for neuroleptics are psychotic features and agitation. Dosage for patients with dementia is different than for other psychotic patients. There is no consensus on the use of other psychoactive medications.

引用

页码：245 / 249

页数：5

共 78 条

[1]

AMADUCCI L, 1987, J NEURAL TRANSM, P287

[2]

AMADUCCI L, 1988, PSYCHOPHARMACOL BULL, V24, P130

[3] ADVANCES IN ALZHEIMER THERAPY - CHOLINESTERASE-INHIBITORS [J].

ASHFORD, JW ;

SHERMAN, KA ;

KUMAR, V .

NEUROBIOLOGY OF AGING, 1989, 10 (01) :99-105

[4]

BARNES R, 1982, AM J PSYCHIAT, V139, P1170

[5] THE CHOLINERGIC HYPOTHESIS OF GERIATRIC MEMORY DYSFUNCTION [J].

BARTUS, RT ;

DEAN, RL ;

BEER, B ;

LIPPA, AS .

SCIENCE, 1982, 217 (4558) :408-417

[6]

BATTAGLIA A, 1989, J AM GERIATR SOC, V37, P295

[7] PSYCHOACTIVE MEDICATION USE IN INTERMEDIATE-CARE FACILITY RESIDENTS [J].

BEERS, M ;

AVORN, J ;

SOUMERAI, SB ;

EVERITT, DE ;

SHERMAN, DS ;

SALEM, S .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1988, 260 (20) :3016-3020

[8] RISK-FACTORS IN GERIATRIC DRUG PRESCRIBING - A PRACTICAL GUIDE TO AVOIDING PROBLEMS [J].

BEERS, MH ;

OUSLANDER, JG .

DRUGS, 1989, 37 (01) :105-112

[9]

BELLER SA, 1988, J CLIN PSYCHIAT, V49, P400

[10]

BESDINE RW, 1989, GERIATRIC MED, P375

← 1 2 3 4 5 6 7 8 →