SUSCEPTIBILITIES OF BRUCELLA-MELITENSIS ISOLATES TO CLINAFLOXACIN AND 4 OTHER NEW FLUOROQUINOLONES

被引：15

作者：

GARCIARODRIGUEZ, JA ^{[1
]}

SANCHEZ, JEG ^{[1
]}

TRUJILLANO, I ^{[1
]}

SANCHEZ, EG ^{[1
]}

GARCIA, MIG ^{[1
]}

FRESNADILLO, MJ ^{[1
]}

机构：

[1] HOSP CLIN UNIV SALAMANCA,FAC MED,DEPT MICROBIOL & PARASITOL,SALAMANCA,SPAIN

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1995年 / 39卷 / 05期

关键词：

D O I：

10.1128/AAC.39.5.1194

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The susceptibilities of 120 clinical isolates of Brucella melitensis and 3 reference strains of the same species to six fluoroquinolones (clinafloxacin, PD 117596, PD 131628, PD 138312, PD 140248, and ciprofloxacin) were examined by agar dilution MIC meth odology. Clinafloxacin was the most active compound tested (MIC at which 50% of strains tested were inhibited [MIC(50)] and MIC(90) of 0.06 mu g/ml). Its level of activity was slightly higher than that of PD 117596 (MIC(50) and MIC(90) of 0.12 mu g/ml). PD 131628 and ciprofloxacin were less active than clinafloxacin, with MIC(50)s ranging from 0.12 to 0.25 mu g/ml and MIC(90)s of between 0.25 and 0.5 mu g/ml for the two compounds. The activity levels of PD 138312 and PD 140248, with MIC(50)s ranging from 1 to 2 mu g/ml and MIC(90)s of 4 to 8 mu g/ml, were lower than those of the other fluoroquinolones tested.

引用

页码：1194 / 1195

页数：2