Progress in the development of Lactococcus lactis as a recombinant mucosal vaccine delivery system

被引：22

作者：

Norton, PM

LePage, RWF

Wells, JM

机构：

[1] Department of Pathology, University of Cambridge, Cambridge

来源：

FOLIA MICROBIOLOGICA | 1995年 / 40卷 / 03期

关键词：

D O I：

10.1007/BF02814197

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The non-pathogenic, non-colonising Gram-positive organism Lactobacillus lactis is beeing developed as an antigen delivery system for mucosal vaccination. A high level expression system has been developed which allows loading of the bacterium with high levels of a heterologous antigen (TTFC) prior to inoculaton. Mucosal inoculaton of one such recombinant strain results in a protective serum antibody response and production of TTFC-specific IgA at mucosal sites.

引用

页码：225 / 230

页数：6

共 10 条

[1]

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