APROTININ IN CHILDREN UNDERGOING CORRECTION OF CONGENITAL HEART-DEFECTS - A DOUBLE-BLIND PILOT-STUDY

被引:37
作者
HERYNKOPF, F
LUCCHESE, F
PEREIRA, E
KALIL, R
PRATES, P
NESRALLA, IA
机构
[1] Department of Cardiac Surgery, Instituto de Cardiologia do Rio Grande do Sul, Porto Alegre
关键词
D O I
10.1016/S0022-5223(94)70262-4
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Thirty children undergoing surgical repair for congenital heart defects were randomly selected for a double-blind study on the antihemorrhagic and blood-saving properties of aprotinin. The treatment group comprised 14 patients who received aprotinin 7 mg/kg of body weight until the end of perfusion. The placebo group (n = 16) received an infusion of the corresponding volumes of saline. Patients treated with aprotinin bled less during the operation (12.6 ml/kg versus 18.1 ml/kg, p = 0.25) and in the first 24 postoperative hours (chest drainage 12.1 ml/kg versus 17.7 ml/kg, p = 0.07). Hemoglobin loss into chest drainage was reduced in the treated group by half (0.66 versus 1.21 gm in 24 hours, p = 0.07). Fewer blood donors were needed during hospitalization by patients receiving aprotinin (1.07 versus 2.75 donors per patient, p = 0.04). Postoperative transfusion was unnecessary in 64.2% of patients receiving aprotinin compared with only 25% of the placebo group (p = 0.03). Aprotinin increased diuresis significantly during perfusion (4.3 ml/kg versus 1.0 ml/kg, p = 0.005). Other parameters are evaluated, and considerations are made regarding adequacy of the dosage regimen. The drug seems to be safe and easy to handle in children.
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页码:517 / 521
页数:5
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