AMIDEPSINES, INHIBITORS OF DIACYLGLYCEROL ACYLTRANSFERASE PRODUCED BY HUMICOLA SP FO-2942 .2. STRUCTURE ELUCIDATION OF AMIDEPSINE-A, AMIDEPSINE-B AND AMIDEPSINE-C

被引：25

作者：

TOMODA, H ^{[1
]}

TABATA, N ^{[1
]}

ITO, M ^{[1
]}

OMURA, S ^{[1
]}

机构：

[1] KITASATO INST,BIOL FUNCT RES CTR,MINATO KU,TOKYO 108,JAPAN

来源：

JOURNAL OF ANTIBIOTICS | 1995年 / 48卷 / 09期

关键词：

D O I：

10.7164/antibiotics.48.942

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Structures of amidepsines A, B, C and D, diacylglycerol acyltransferase (DGAT) inhibitors, were determined by spectroscopic studies including various NMR measurements. They were elucidated as 2-hydroxy-4-[[2-hydroxy-4-[(2,4-dimethoxy-6-methylbenzoyl)oxy]6-methylbenzoyl]-oxy]-6-methylbenzoic acid N-alanine amide for amidepsine A, 2-hydroxy-4-[[2-hydroxy-4-[(2-hydroxy-4-methoxy-6-methylbenzoyl)oxy] 6-methylbenzoyl]oxy]-6-methylbenzoic acid N-alanine amide for amidepsine B and 2-hydroxy-4-[[2-hydroxy-4-[(2-hydroxy-4-methoxy-6-methylbenzoyl)oxy]6-methylbenzoyl]oxy]6-methylbenzoic acid N-valine amide for amidepsine C. Amidepsine D was identified with 2,4-di-O-methylgryphoric acid.

引用

页码：942 / 947

页数：6

共 5 条

[1] 2,4-DI-O-METHYLGYROPHORIC ACID AND 2,4,5-TRI-O-METHYLHIASCIC ACID - NEW TRIDEPSIDES FROM PARMELIA-DAMAZIANA [J].

ELIX, JA ;

JAYANTHI, VK ;

LEZNOFF, CC .

AUSTRALIAN JOURNAL OF CHEMISTRY, 1981, 34 (08) :1757-1761

[2]

FRESENIUS W, 1989, TABLES SPECTRAL DATA, pC120

[3]

SUNAZUKA T, 1993, TETRAHEDRON LETT, V4, P6659

[4]

TAKIKAWA H, 1992, 34TH S CHEM NAT PROD, P707

[5] AMIDEPSINES, INHIBITORS OF DIACYLGLYCEROL ACYLTRANSFERASE PRODUCED BY HUMICOLA SP FO-2942 .1. PRODUCTION, ISOLATION AND BIOLOGICAL PROPERTIES [J].

TOMODA, H ;

ITO, M ;

TABATA, N ;

MASUMA, R ;

YAMAGUCHI, Y ;

OMURA, S .

JOURNAL OF ANTIBIOTICS, 1995, 48 (09) :937-941

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