NEONATAL MONOSODIUM GLUTAMATE TREATMENT PREVENTS EFFECTS OF CONSTANT LIGHT ON CIRCADIAN TEMPERATURE RHYTHMS OF ADULT-RATS

被引:36
作者
EDELSTEIN, K
PFAUS, JG
RUSAK, B
AMIR, S
机构
[1] CONCORDIA UNIV,DEPT PSYCHOL,CTR STUDIES BEHAV NEUROBIOL,MONTREAL,PQ H3G 1M8,CANADA
[2] DALHOUSIE UNIV,DEPT PSYCHOL,HALIFAX,NS B3H 4J1,CANADA
基金
英国医学研究理事会;
关键词
CIRCADIAN RHYTHM; MONOSODIUM GLUTAMATE; SUPRACHIASMATIC NUCLEUS; INTERGENICULATE LEAFLET; PHOTIC STIMULATION; CONSTANT LIGHT; FOS IMMUNOCYTOCHEMISTRY;
D O I
10.1016/0006-8993(95)00048-U
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Housing rats under continuous illumination (LL) disrupts circadian rhythms controlled by a pacemaker located in the hypothalamic suprachiasmatic nucleus (SCN). The neural mechanisms underlying this effect are not well understood. The present study examined the effects of LL on circadian rhythms and on light-induced expression of Fos protein in the SCN, intergeniculate leaflet (IGL), and ventrolateral geniculate nucleus (vLGN) in adult rats treated neonatally with monosodium glutamate (MSG). Such treatment is known to lead to acute degeneration of retinal ganglion cells. Despite degeneration of the optic nerve, neonatal MSG treatment (2 mg/g SC on postnatal days 1,3,5,7, and 9) had no effect on daily temperature rhythms in the adult animal under a light-dark cycle. However, the disintegration of circadian rhythms under LL conditions observed in adult rats treated neonatally with 10% saline was prevented in MSG-treated rats. Furthermore, neonatal MSG treatment attenuated light-induced expression of Fos protein in the IGL and vLGN, but not in the SCN. These data suggest that neonatal MSG treatment alters the response of the circadian system to LL and that cells within the IGL/vLGN region may mediate this response.
引用
收藏
页码:135 / 142
页数:8
相关论文
共 28 条
[1]   NEUROTOXIC EFFECTS OF NEONATAL INJECTIONS OF MONOSODIUM L-GLUTAMATE (L-MSG) ON THE RETINAL GANGLION-CELL LAYER OF THE GOLDEN-HAMSTER - ANATOMICAL AND FUNCTIONAL CONSEQUENCES ON THE CIRCADIAN SYSTEM [J].
CHAMBILLE, I ;
SERVIERE, J .
JOURNAL OF COMPARATIVE NEUROLOGY, 1993, 338 (01) :67-82
[2]   AN ELECTRON MICROSCOPIC STUDY OF MODIFICATION BY MONOSODIUM GLUTAMATE OF RETINAS OF NORMAL AND RODLESS MICE [J].
COHEN, AI .
AMERICAN JOURNAL OF ANATOMY, 1967, 120 (02) :319-+
[3]  
EDELSTEINK, 1993, SOC NEUR ABSTR, V19, P571
[4]  
FOSTER RG, 1993, J BIOL RHYTHM, V8, pS17
[5]   CIRCADIAN PHOTORECEPTION IN THE RETINALLY DEGENERATE MOUSE (RD/RD) [J].
FOSTER, RG ;
PROVENCIO, I ;
HUDSON, D ;
FISKE, S ;
DEGRIP, W ;
MENAKER, M .
JOURNAL OF COMPARATIVE PHYSIOLOGY A-SENSORY NEURAL AND BEHAVIORAL PHYSIOLOGY, 1991, 169 (01) :39-50
[7]  
GWINNER E, 1987, Journal of Biological Rhythms, V2, P109, DOI 10.1177/074873048700200203
[8]   ABLATION OF THE GENICULO-HYPOTHALAMIC TRACT ALTERS CIRCADIAN ACTIVITY RHYTHMS OF HAMSTERS HOUSED UNDER CONSTANT LIGHT [J].
HARRINGTON, ME ;
RUSAK, B .
PHYSIOLOGY & BEHAVIOR, 1988, 42 (02) :183-189
[9]  
Kizer J. S., 1978, PHARMACOL REV, V29, P301
[10]   PHOTIC AND CIRCADIAN REGULATION OF C-FOS-GENE EXPRESSION IN THE HAMSTER SUPRACHIASMATIC NUCLEUS [J].
KORNHAUSER, JM ;
NELSON, DE ;
MAYO, KE ;
TAKAHASHI, JS .
NEURON, 1990, 5 (02) :127-134