ISOLATION OF NITROGEN DEREGULATED MUTANTS OF ERYTHROMYCIN BIOSYNTHESIS

被引：4

作者：

FLORES, ME

机构：

[1] Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, México, 04510, D.F.

来源：

BIOTECHNOLOGY LETTERS | 1991年 / 13卷 / 02期

关键词：

D O I：

10.1007/BF01030459

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Ammonium represses erythromycin synthesis by Saccharopolyspora erythraea and insensitive mutants to this effect were isolated. Six mutants were selected and one of them produces 50% more antibiotic than the wild type in 100 mM NH4Cl as nitrogen source. Glutamine synthetase and alanine dehydrogenase levels in the mutants were determined and no differences with wild type strain were observed.

引用

页码：101 / 106

页数：6

共 15 条

[1]

BASCARAN V, 1989, J GEN MICROBIOL, V135, P2475

[2]

BASCARAN V, 1989, J GEN MICROBIOL, V135, P2465

[3]

CASTRO JM, 1985, APPL MICROBIOL BIOT, V22, P32

[4] AN UNUSUALLY LARGE MULTIFUNCTIONAL POLYPEPTIDE IN THE ERYTHROMYCIN-PRODUCING POLYKETIDE SYNTHASE OF SACCHAROPOLYSPORA-ERYTHRAEA [J].