SEROTONERGIC EXCITATORY DRIVE TO HYPOGLOSSAL MOTONEURONS IN THE DECEREBRATE CAT

被引：187

作者：

KUBIN, L

TOJIMA, H

DAVIES, RO

PACK, AI

机构：

[1] UNIV PENN,SCH MED,CTR SLEEP & RESP NEUROBIOL,PHILADELPHIA,PA 19104

[2] UNIV PENN,SCH VET MED,DEPT ANIM BIOL,PHILADELPHIA,PA 19104

来源：

NEUROSCIENCE LETTERS | 1992年 / 139卷 / 02期

关键词：

SEROTONIN; HYPOGLOSSAL MOTONEURON; GENIOGLOSSAL MOTONEURON; DECEREBRATE CAT; SLEEP APNEA; RESPIRATION; UPPER AIRWAY; MICROINJECTION;

D O I：

10.1016/0304-3940(92)90563-M

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In decerebrate, paralyzed, vagotomized and artificially ventilated cats, serotonin (5-HT) and its analogues, microinjected into the hypoglossal (XII) motor nucleus, altered the activity of the genioglossal branch of XII nerve. 5-HT, carboxamidotryptamine maleate (5-CT) and DOI (1-5 mM) increased the activity by over 200%. Methysergide reversed this increase. Methysergide, mianserin, or ketanserin (100-250 nl, 1 mM) reduced the spontaneous hypoglossal activity by 20-50%. Buspirone, 8-OH-DPAT and (-)-propranolol were without effect. Thus, 5-HT provides a substantial tonic excitatory drive to XII motoneurons. The 5-HT receptors involved are likely to be type 1C or 2, but uncertainty regarding the affinity profiles of the drugs used in in vivo conditions in the cat precludes a definite identification.

引用

页码：243 / 248

页数：6

共 30 条

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