COMPARATIVE-ASSESSMENT OF SINGLE-DOSE AND FRACTIONATED BORON NEUTRON-CAPTURE THERAPY

被引:33
作者
CODERRE, JA [1 ]
MORRIS, GM [1 ]
MICCA, PL [1 ]
FISHER, CD [1 ]
ROSS, GA [1 ]
机构
[1] UNIV OXFORD, CHURCHILL HOSP,RES INST,CRC, NORMAL TISSUE RADIOBIOL RES GRP, OXFORD OX3 7LJ, ENGLAND
关键词
D O I
10.2307/3578951
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
The effects of fractionating boron neutron capture therapy (BNCT) were evaluated in the intracerebral rat 9L gliosarcoma and rat spinal cord models using the Brookhaven Medical Research Reactor (BMRR) thermal neutron beam. The amino acid analog p-boronophenylalanine (BPA) was administered prior to each exposure to the thermal neutron beam, The total physical absorbed dose to the tumor during BNCT using BPA was 91% high-linear energy transfer (LET) radiation, Two tumor doses of 5.2 Gy spaced 48 h apart (n = 14) or three tumor doses of 5.2 Gy, each separated by 48 h (n = 10), produced 50 and 60% long-term (>1 year) survivors, respectively. The outcome of neither the two nor the three fractions of radiation was statistically different from that of the corresponding single-fraction group. In the rat spinal cord,the ED(50) for radiation myelopathy (as indicated by limb paralysis within 7 months) after exposure to the thermal beam alone was 13.6 +/- 0.4 Gy. Dividing the beam-only irradiation into two or four consecutive daily fractions increased the ED(50) to 14.7 +/- 0.2 Gy and 15.5 +/- 0.4 Gy, respectively, Thermal neutron irradiation in the presence of BPA resulted in an ED(50) for myelopathy of 13.8 +/- 0.6 Gy after a single fraction and 14.9 +/- 0.9 Gy after two fractions. An increase in the number of fractions to four resulted in an ED(50) of 14.3 +/- 0.6 Gy, The total physical absorbed dose to the blood in the vasculature of the spinal cord during BNCT using BPA was 80% high-LET radiation. It was observed that fractionation was of minor significance in the amelioration of damage to the normal central nervous system in the rat after boron neutron capture irradiation. (C) 1995 by Radiation Research Society
引用
收藏
页码:310 / 317
页数:8
相关论文
共 30 条
[1]  
BARTH RF, 1990, CANCER RES, V50, P1061
[2]   CONTROL OF INTRACEREBRAL GLIOSARCOMAS IN RATS BY BORON NEUTRON-CAPTURE THERAPY WITH PARA-BORONOPHENYLALANINE [J].
CODERRE, JA ;
JOEL, DD ;
MICCA, PL ;
NAWROCKY, MM ;
SLATKIN, DN .
RADIATION RESEARCH, 1992, 129 (03) :290-296
[3]   NEUTRON-CAPTURE THERAPY OF THE 9L RAT GLIOSARCOMA USING THE P-BORONOPHENYLALANINE-FRUCTOSE COMPLEX [J].
CODERRE, JA ;
BUTTON, TM ;
MICCA, PL ;
FISHER, CD ;
NAWROCKY, MM ;
LIU, HB .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1994, 30 (03) :643-652
[4]   DERIVATIONS OF RELATIVE BIOLOGICAL EFFECTIVENESS FOR THE HIGH-LET RADIATIONS PRODUCED DURING BORON NEUTRON-CAPTURE IRRADIATIONS OF THE 9L RAT GLIOSARCOMA IN-VITRO AND IN-VIVO [J].
CODERRE, JA ;
MAKAR, MS ;
MICCA, PL ;
NAWROCKY, MM ;
LIU, HYB ;
JOEL, DD ;
SLATKIN, DN ;
AMOLS, HI .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1993, 27 (05) :1121-1129
[5]  
CODERRE JA, 6TH P INT S NEUTR CA
[6]  
CODERRE JA, 1994, TOPICS DOSIMETRY TRE, P37
[7]   MICROANALYTICAL TECHNIQUES FOR BORON ANALYSIS USING THE B-10(N,ALPHA)LI-7 REACTION [J].
FAIRCHILD, RG ;
GABEL, D ;
LASTER, BH ;
GREENBERG, D ;
KISZENICK, W ;
MICCA, PL .
MEDICAL PHYSICS, 1986, 13 (01) :50-56
[8]  
FARR LE, 1954, AM J ROENTGENOL, V71, P279
[9]   RBE FOR LATE SPINAL-CORD INJURY FOLLOWING MULTIPLE FRACTIONS OF NEUTRONS [J].
GERACI, JP ;
JACKSON, KL ;
CHRISTENSEN, GM ;
THROWER, PD ;
MARIANO, M .
RADIATION RESEARCH, 1978, 74 (02) :382-386
[10]   CLINICAL-RESULTS OF LONG-SURVIVING BRAIN-TUMOR PATIENTS WHO UNDERWENT BORON NEUTRON-CAPTURE THERAPY [J].
HATANAKA, H ;
NAKAGAWA, Y .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1994, 28 (05) :1061-1066