PROSTAGLANDIN E(2) STIMULATES GLUTAMATE RELEASE FROM SYNAPTOSOMES OF RAT SPINAL-CORD

被引：59

作者：

NISHIHARA, I

MINAMI, T

WATANABE, Y

ITO, S

HAYAISHI, O

机构：

[1] OSAKA BIOSCI INST,DEPT MOLEC BEHAV BIOL,SUITA,OSAKA 565,JAPAN

[2] OSAKA MED COLL,DEPT ANESTHESIOL,TAKATSUKI,OSAKA 569,JAPAN

[3] OSAKA BIOSCI INST,DEPT NEUROSCI,SUITA,OSAKA 565,JAPAN

[4] KANSAI MED UNIV,DEPT MED CHEM,MORIGUCHI,OSAKA 570,JAPAN

来源：

NEUROSCIENCE LETTERS | 1995年 / 196卷 / 1-2期

关键词：

PROSTAGLANDIN E(2); SPINAL CORD; SYNAPTOSOMES; SUPERFUSION; GLUTAMATE; PRESYNAPTIC REGULATION;

D O I：

10.1016/0304-3940(95)11839-O

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We recently reported that intrathecal administration of prostaglandin E(2) induced hyperalgesic and allodynic effects through the glutamate receptor system. Here we examined whether prostaglandin E(2) could evoke amino acid release from nerve terminals using rat spinal cord synaptosomes. Exposure in superfusion to prostaglandin Ep significantly increased endogenous glutamate and aspartate release and dose dependencies showed bell-shaped patterns with a peak at 1 nM. Both releases were almost absolutely Ca2+-dependent. These results demonstrate that prostaglandin E(2) may stimulate the release of excitatory amino acids presynaptically in the spinal cord.

引用

页码：57 / 60

页数：4

共 31 条

[1] PERIPHERAL AND SPINAL MECHANISMS OF NOCICEPTION [J].