ANTAGONIZING EFFECTS OF VA-045 ON REDUCED ACTIVITY OF RAT LOCUS-COERULEUS NEURONS FOLLOWING HEAD-INJURY OR INTRAVENOUS-INJECTION OF CLONIDINE

被引：6

作者：

ARAKAWA, S

NAKAMURA, S

KAWASHIMA, N

NISHIIKE, S

OKUYAMA, S

机构：

[1] YAMAGUCHI UNIV, SCH MED, DEPT PHYSIOL, UBE, YAMAGUCHI 755, JAPAN

[2] KANAZAWA UNIV, FAC MED, DEPT PHYSIOL, KANAZAWA, ISHIKAWA 920, JAPAN

[3] TAISHO PHARMACEUT CO LTD, MED RES LABS, 1ST LAB, OMIYA, SAITAMA 330, JAPAN

[4] OSAKA UNIV, SCH MED, DEPT OTOLARYNGOL, SUITA, OSAKA 565, JAPAN

来源：

LIFE SCIENCES | 1995年 / 57卷 / 19期

关键词：

VA-045; LOCUS COERULEUS; HEAD INJURY; CLONIDINE; CONSCIOUSNESS;

D O I：

10.1016/0024-3205(95)02158-F

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Based on the finding that VA-045, a novel apovincaminic acid derivative, had improved disturbance in consciousness, we examined the effects of the drug an the electrical activity of locus coeruleus (LC) neurons in animal models of consciousness disturbance. The animal models of consciousness disturbance used in this experiment were closed head injury (CHI) and intravenous injection of clonidine. CHI as well as clonidine injection reduced the spontaneous activity of LC neurons. The reduction of the spontaneus activity of LC neurons following CHI or clonidine injection was restored by intravenous injection of VA-045. The change of LC neuronal activity induced by VA-045 preceded desynchronization of EEG. These results suggest that VA-045 exerts its ameliorating effect on consciousness disturbance, at least in part, by augmenting the spontaneous activity of noradrenergic LC neurons.

引用

页码：1803 / 1810

页数：8

共 24 条

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