BETA-GLYCOSIDASES AND DIABETIC MICROANGIOPATHY .1. DECREASES OF BETA-GLYCOSIDASE ACTIVITIES IN DIABETIC RAT-KIDNEY

被引：88

作者：

FUSHIMI, H ^{[1
]}

TARUI, S ^{[1
]}

机构：

[1] OSAKA UNIV, MED SCH, DEPT INTERN MED, OSAKA 553, OSAKA, JAPAN

来源：

JOURNAL OF BIOCHEMISTRY | 1976年 / 79卷 / 02期

关键词：

D O I：

10.1093/oxfordjournals.jbchem.a131066

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Deposition of periodic acid Schiff-positive materials and thickening of the basement membrane in vascular lesions are characteristics findings in diabetes mellitus, suggesting altered metabolism of glycoprotein. Changes in the activities of the glycosidases, .beta.-N-acetylglucosaminidase [EC 3.2.1.30], .beta.-glucuronidase [EC 3.2.1.31], .beta.-galactosidase [EC 3.2.1.23] and .beta.-glucosidase [EC 3.2.1.21] were measured in various organs and the serum of diabetic rats. The activities of the 1st 3 enzymes were much reduced in the kidney but increased in the serum. The decreased activities of .beta.-glycosidases in the kidney may be 1 of the factors responsible for the pathogenesis of microangiopathy.

引用

页码：265 / 270

页数：6

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