MECHANISM OF ACTION OF ANGIOTENSIN-CONVERTING ENZYME (ACE) INHIBITORS IN HYPERTENSION AND HEART-FAILURE - ROLE OF PLASMA VERSUS TISSUE ACE

被引：34

作者：

DZAU, VJ

机构：

[1] Division of Vascular Medicine, Brigham

[2] Women’S Hospital, Harvard Medical School, Boston, Massachusetts

来源：

DRUGS | 1990年 / 39卷

关键词：

D O I：

10.2165/00003495-199000392-00004

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The contribution of plasma versus tissue angiotensin-converting enzyme (ACE) to pathophysiology and drug effect is reviewed. The data suggest that tissue ACE is important in influencing local angiotensin levels and that the long term response to an ACE inhibitor is dependent on its action on tissue ACE. The tissue penetration and distribution of various ACE inhibitors may determine their duration of action and the relative effects on different organs, thereby influencing regional blood flow and tissue function. This concept of tissue ACE has improved our understanding of the mechanisms of action of ACE inhibition in the treatment of hypertension and heart failure. © 1990, ADIS Press Limited. All rights reserved.

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页码：11 / 16

页数：6

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