BIOLOGICAL-ACTIVITY OF 1-ALPHA,25-DIHYDROXYVITAMIN-D DERIVATIVES - 24-EPI-1-ALPHA,25-DIHYDROXYVITAMIN-D-2 AND 1-ALPHA,25-DIHYDROXYVITAMIN-D-7

被引：13

作者：

SATO, F

OKAMOTO, Y

OUCHI, Y

KANEKI, M

NAKAMURA, T

IKEKAWA, N

ORIMO, H

机构：

[1] UNIV TOKYO,FAC MED,DEPT GERIATR,7-3-1 HONGO,BUNKYO KU,TOKYO 113,JAPAN

[2] IWAKI MEISEI UNIV,FAC SCI & TECHNOL,IWAKI,JAPAN

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1991年 / 1091卷 / 02期

关键词：

VITAMIN-D; 24-EPI-1-ALPHA; 25-DIHYDROXYVITAMIN-D-2; 1-ALPHA; 25-DIHYDROXYVITAMIN-D-7; CALCIUM METABOLISM; LEUKEMIA DIFFERENTIATION;

D O I：

10.1016/0167-4889(91)90060-B

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Biological activity of 24-epi-1-alpha,25-dihydroxyvitamin D-2 (24-epi-1,25(OH)2D2) and 1-alpha,25-dihydroxyvitamin D-7 (1,25(OH)2D7), the 22,23-dihydro derivative of the former compound, was investigated. Both of the vitamin D derivatives stimulated intestinal calcium transport and calcium mobilization from bones in rats; however, the effect was about 50% of that of 1-alpha,25-dihydroxyvitamin D-3 (1,25(OH)2D3). On the other hand, 24-epi-1,25(OH)2D2 and 1,25(OH)2D7 inducement of HL-60 human leukemia cell differentiation was comparable to that of 1,25(OH)2D3. Accordingly, the differentiation-inducing activity of 24-epi-1,25(OH)2D2 and 1,25(OH)2D7 was much greater than their ability to stimulate calcium metabolism. In contrast to 1,25(OH)2D3, 24-epi-1,25(OH)2D2 and 1,25(OH)2D7 exerted little hypercalcemic activity in mice. These results suggest that both vitamin D derivatives will be useful as anti-tumor agents.

引用

页码：188 / 192

页数：5

共 17 条

[1] SYNTHETIC ANALOGS OF VITAMIN-D3 WITH AN OXYGEN ATOM IN THE SIDE-CHAIN SKELETON - A TRAIL OF THE DEVELOPMENT OF VITAMIN-D COMPOUNDS WHICH EXHIBIT POTENT DIFFERENTIATION-INDUCING ACTIVITY WITHOUT INDUCING HYPERCALCEMIA [J].