SYSTEMIC LUPUS-ERYTHEMATOSUS IN 18 BRAZILIAN MALES - CLINICAL AND LABORATORY ANALYSIS

被引:17
作者
COSTALLAT, LTL [1 ]
COIMBRA, AMV [1 ]
机构
[1] STATE UNIV CAMPINAS,DEPT INTERNAL MED,DIV RHEUMATOL,CAMPINAS,SP,BRAZIL
关键词
SYSTEMIC LUPUS ERYTHEMATOSUS; MALE LUPUS; SEX FACTORS;
D O I
10.1007/BF02231783
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The clinical and laboratory features of 18 males were compared with 254 female patients with systemic lupus erythematosus (SLE). At disease onset male patients were younger than female. Nephropathy, nephrotic syndrome and thrombocytopenia were significantly more frequent in male patients (p<0.05). Pleuritis occurred as the initial symptom at a significantly higher frequency in males (p<0.05). No significant immunological difference was found between two groups, except for anti-Sm antibodies which were more frequent in males than in females, but were measured in few patients. We concluded that male patients with SLE have a more severe disease with higher morbidity, specially related to renal disease.
引用
收藏
页码:522 / 525
页数:4
相关论文
共 27 条
[1]  
Lahita R.G., Chiorazzi N., Gibofsky A., Winchester R.J., Kunkel H.G., Familial systemic lupus erythematosus in males, Arthritis Rheum, 26, 1, pp. 39-44, (1983)
[2]  
Lahita R.G., Bradlow H.L., Kunkel H.G., Fishman J., Increased 16 alpha hydroxilation of estradiol in SLE, J Clin Endocrinol Metabol, 53, 1, pp. 174-178, (1981)
[3]  
Inman R.D., Jovanovic L., Markeson J.A., Systemic lupus erythematosus in man. Genetic and endocrine features, Arch Int Med, 142, pp. 1813-1815, (1982)
[4]  
Steinberg A.D., Melez K.A., Raveche E.S., Et al., Approach to the study of the role of sex hormones in autoimmunity, Arthritis Rheum, 22, pp. 1170-1176, (1979)
[5]  
Miller H.M., Urowitz M.H., Gladman D.D., Killinger D.W., Systemic lupus erythematosus in males, Medicine, 62, pp. 327-334, (1983)
[6]  
Hochberg M.C., Boyd R.E., Ahearn J.M., Et al., Systemic lupus erythematosus: a review of clinico-laboratory features and immunogenetic markers in 150 patients with emphasis on demographic subsets, Medicine, 64, pp. 285-295, (1985)
[7]  
Aydintug A.D., Domenech I., Cervera R., Khamashta M.A., Jedryka-Goral A., Vianna J.L., Hughes G.R.V., Systemic lupus erythematosus in males: analysis of clinical and laboratory features, Lupus, 1, pp. 295-298, (1992)
[8]  
Austin H.A., Muenz L.R., Joyce K.M., Et al., Prognostic factors in lupus nephritis. Contribution of renal histologic data, Am J Med, 75, pp. 382-391, (1983)
[9]  
Kaufman L.D., Gomez-Reino J.J., Heinicke M.H., Gorevic P.D., Male lupus retrospective analysis of the clinical and laboratory feature of 52 patients, with a review of the literature, Semin Arthritis Rheum, 18, 3, pp. 189-197, (1989)
[10]  
Folomeev M., Alekberova Z., Survival pattern of 120 males with systemic lupus erythematosus, J Rheumatol, 17, 6, pp. 856-858, (1990)