ILOPROST ENHANCES SURVIVAL OF AXIAL-PATTERN SKIN FLAPS IN AN ISCHEMIA-REPERFUSION MODEL

被引：13

作者：

RAJAGOPAL, U ^{[1
]}

FRIEDMAN, RM ^{[1
]}

ROBINSON, JB ^{[1
]}

ROHRICH, RJ ^{[1
]}

机构：

[1] UNIV TEXAS,SW MED CTR,DEPT SURG,DIV PLAST & RECONSTRUCT SURG,DALLAS,TX 75235

来源：

PLASTIC AND RECONSTRUCTIVE SURGERY | 1995年 / 95卷 / 05期

关键词：

D O I：

10.1097/00006534-199595050-00018

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Iloprost, a stable prostacyclin analogue, significantly enhances the survival of an axial-pattern groin flap in rats after ischemia-reperfusion. Treated flaps showed viability over 90 percent of their area 7 days after an 8-hour ischemic episode, whereas the saline-treated controls were viable over only 20 percent of their area (p = 0.002). This effect was seen at a low (10 ng/kg) dosage, and no apparent side effects were noted.

引用

页码：884 / 887

页数：4

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