SPECTROPHOTOMETRIC DETERMINATION OF DICLOFENAC SODIUM WITH METHYLENE-BLUE

被引：93

作者：

BOTELLO, JC ^{[1
]}

PEREZCABALLERO, G ^{[1
]}

机构：

[1] Univ Nacl Autonoma Mexico, FAC ESTUDIOS SUPER CUAUTITLAN, SECC QUIM ANALIT, MEXICO CITY 54740, DF, MEXICO

来源：

TALANTA | 1995年 / 42卷 / 01期

关键词：

D O I：

10.1016/0039-9140(94)00224-G

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A sensitive spectrophotometric method was established for the determination od Diclofenac sodium (DS) with Methylene Blue (MB) as analytical reagent. It was found that DS reacts with an excess of MB in the pH range 9.2-9.4, to form a chloroform-extractable blue ion-association complex. Good agreement with Beer's law was found in the range of DS concentrations of 0.8-6.4 mu g/ml with a detection limit of 0.37 mu g/ml. The method was applied for the determination of DS in various tableted forms with a good precision.

引用

页码：105 / 108

页数：4

共 13 条

[1]

ARRAWAL K, 1988, INDIAN J PHARM SCI, V50, P58

[2] A RAPID AND SENSITIVE METHOD FOR THE DETERMINATION OF DICLOFENAC SODIUM IN PLASMA BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY [J].