OVULATION SIDE AND OVARIAN-CANCER

被引:18
作者
BALASCH, J
PENARRUBIA, J
MARQUEZ, M
MIRKIN, SR
CARMONA, F
BARRI, PN
VANRELL, JA
机构
[1] Department of Obstetrics and Gynecology, University of Barcelona, Barcelona
[2] Department of Histopathology, Hospital Clínic i Provincial, University of Barcelona, Barcelona
[3] Service of Reproductive Medicine, Institut Universitari Dexeus, Barcelona
关键词
OVULATION SIDE; OVARIAN CANCER;
D O I
10.3109/09513599409028458
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Previous reports have suggested a predilection for right-sided ovulation and that epithelial ovarian cancer arises more commonly in the right ovary, thus establishing a possible causal relationship between ovulation and ovarian cancer. However, evaluation of ovulation patterns in consecutive cycles has produced contradictory results and there are no reports corroborating a higher incidence of right-sided ovarian cancers. We reviewed the records of 293 patients with epithelial ovarian cancer and found no significant difference between the frequency of tumors in the right and left ovaries. We also prospectively analyzed the side of ovulation in 41 unselected consecutive patients undergoing 156 in vitro fertilization cycles without ovarian stimulation, Follicular development was carefully monitored by daily ultrasonic scan and estradiol and LH plasma determinations. Eighty-two ovulations (52%) were on the right (not statistically significant). Thus our results bring into question previous studies suggesting a link between the side of ovulation and epithelial ovarian cancer.
引用
收藏
页码:51 / 54
页数:4
相关论文
共 28 条
[1]  
Fathalla M.F., Incessant ovulation — a factor in ovarian neoplasia?, Lancet, 2, (1971)
[2]  
Casagrande J.T., Pike M.C., Ross R.K., Louie E.W., Roy S., Henderson B.E., ‘Incessant ovulation’ and ovarian cancer, Lancet, 2, pp. 170-172, (1979)
[3]  
Cruickshank D.J., Aetiological importance of ovulation in epithelial ovarian cancer: A population based study, Br. Med. J., 301, pp. 524-525, (1990)
[4]  
Fishel S., Jackson P., Follicular stimulation for high-tech pregnancies: are we playing it safe?, Br. Med, 299, pp. 309-311, (1989)
[5]  
Whittemore A.S., Harris R., Itnyre J., Characteristics relating to ovarian cancer risk: collaborative analysis of 12 US case-control studies. II: Invasive epithelial ovarian cancers in white women, Am. J. Epidemiol., 136, pp. 1184-1203, (1992)
[6]  
Balasch J., Barri P.N., Follicular stimulation and ovarian cancer?, Hum. Reprod., 8, pp. 990-996, (1993)
[7]  
Cohen J., Forman R., Harlap S., Johannisson E., Lunenfeld B., de Mouzon J., Pepperell R., Tarlatzis B., Templeton A., IFFS Expert Group Report on the Whittemore study related to the risk of ovarian cancer associated with the use of infertility drugs, Hum. Reprod., 8, pp. 996-999, (1993)
[8]  
Whittemore A., Fertility drugs and risk of ovarian cancer, Hum. Reprod., 8, pp. 999-1000, (1993)
[9]  
Foulot H., Ranoux C., Dubuisson J., Rambaud D., Aubriot F., Poirot C., In vitro fertilization without ovarian stimulation: a simplified protocol applied in 80 cycles, Fed. Steril., 52, pp. 617-621, (1989)
[10]  
Heintz A., Hacker N., Lagasse L., Epidemiology and etiology of ovarian cancer: a review, Obstet. Gynecol., 66, pp. 127-135, (1985)