A NEW REARRANGEMENT OF OXETANE-TYPE TAXOIDS

被引：9

作者：

APPENDINO, G

VARESE, M

GARIBOLDI, P

GABETTA, B

机构：

[1] DIPARTIMENTO SCI CHIM,I-62032 CAMERINO,ITALY

[2] INDENA SPA,I-20141 MILAN,ITALY

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 14期

关键词：

D O I：

10.1016/S0040-4039(00)76801-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Treatment of 7-triethylsilyl-14 beta-hydroxy-10-deacetylbaccatin III (1b) with pyridinium p-toluenesulfonate in refluxing benzene gave the orthoester 3 as a result of O(2) --> O(14) benzoate migration, contraction of ring A followed by formation of an ether bridge between C(15) and C(10), and rearrangement of the 4-acetoxy-5(20)-oxetane moiety into a C(5)-epimerized 2,4,20-orthoacetate.

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页码：2217 / 2220

页数：4

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