CHARACTERIZATION OF C-18-BONDED SILICAS FOR SOLID-PHASE EXTRACTION BY SOLID-STATE NMR-SPECTROSCOPY

被引：30

作者：

ALBERT, K

BRINDLE, R

MARTIN, P

WILSON, ID

机构：

[1] ZENECA PHARMACEUT,DEPT SAFETY MED,MACCLESFIELD SK10 4TG,CHESHIRE,ENGLAND

[2] INST ORGAN CHEM,TUBINGEN,GERMANY

来源：

JOURNAL OF CHROMATOGRAPHY A | 1994年 / 665卷 / 02期

关键词：

D O I：

10.1016/0021-9673(94)85055-0

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Si-29 and C-13 cross-polarisation magic-angle-spinning (CP-MAS) NMR spectroscopy have been used to characterise a total of seven C-18-bonded silicas used for solid-phase extraction. Wide variations were observed in the extraction properties of these silicas for basic analytes such as the drug propranolol. These differences depended upon the degree of carbon loading of the phases and whether or not endcapping had been performed. The different properties of the phases appear to correlate well with the differences observed using CP-MAS NMR. This demonstrates the utility of such techniques as a means of further understanding the underlying mechanisms responsible for the observed extraction properties of the phases.

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页码：253 / 258

页数：6

相关论文

共 12 条

[1]

ALBERT K, 1992, CHEM MOD S, V4, P105

[2] CHARACTERIZATION OF BONDED PHASES BY SOLID-STATE NMR-SPECTROSCOPY [J].

ALBERT, K ;

BAYER, E .

JOURNAL OF CHROMATOGRAPHY, 1991, 544 (1-2) :345-370

[3]

ALBERT K, 1988, CHEM MODIFIED SURFAC, V2, P287

[4] CHARACTERIZATION OF CHEMICALLY MODIFIED SILICA-GELS BY SI-29 AND C-13 CROSS-POLARIZATION AND MAGIC ANGLE SPINNING NUCLEAR MAGNETIC-RESONANCE [J].

BAYER, E ;

ALBERT, K ;

REINERS, J ;

NIEDER, M ;

MULLER, D .

JOURNAL OF CHROMATOGRAPHY, 1983, 264 (02) :197-213

[5] REVERSED-PHASE CHROMATOGRAPHIC AND NUCLEAR-MAGNETIC-RESONANCE STUDIES OF BIDENTATE ALKYLSILANE-MODIFIED SILICA [J].

GILPIN, RK ;

GANGODA, ME .

JOURNAL OF CHROMATOGRAPHIC SCIENCE, 1990, 28 (06) :277-281

[6] FUNDAMENTAL-STUDIES IN REVERSED-PHASE LIQUID SOLID EXTRACTION OF BASIC DRUGS .1. IONIC INTERACTIONS [J].

LAW, B ;

WEIR, S ;

WARD, NA .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 1992, 10 (2-3) :167-179

[7] SI-29 NUCLEAR MAGNETIC-RESONANCE STUDY OF THE SURFACE OF SILICA-GEL BY CROSS POLARIZATION AND MAGIC-ANGLE SPINNING [J].

MACIEL, GE ;

SINDORF, DW .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1980, 102 (25) :7606-7607

[8] AN INVESTIGATION OF THE EFFECTS OF CARBON LOADING AND ENDCAPPING ON THE SOLID-PHASE EXTRACTION OF BETA-BLOCKERS ONTO C18 BONDED SILICA-GEL [J].

MARTIN, P ;

TABERNER, J ;

FAIRBROTHER, A ;

WILSON, ID .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 1993, 11 (08) :671-677

[9] INVESTIGATIONS BY SI-29 CROSS-POLARIZATION MAGIC ANGLE SPINNING NMR-SPECTROSCOPY OF REACTION PATHWAYS OF SILICA-GEL POLYFUNCTIONAL MODIFICATION [J].

PFLEIDERER, B ;

ALBERT, K ;

BAYER, E .

JOURNAL OF CHROMATOGRAPHY, 1990, 506 :343-355

[10] THE USE OF GRAPHITIZED CARBON-BLACK IN SOLID-PHASE EXTRACTION - COMPARISON WITH C-18 BONDED SILICA-GEL [J].

ROBERTS, DW ;

RUANE, RJ ;

WILSON, ID .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 1989, 7 (09) :1077-1086