CHIRAL ARENETHIOLATOCOPPER(I) CATALYZED SUBSTITUTION-REACTIONS OF ACYCLIC ALLYLIC SUBSTRATES WITH GRIGNARD-REAGENTS

被引：118

作者：

VANKLAVEREN, M

PERSSON, ESM

DELVILLAR, A

GROVE, DM

BACKVALL, JE

VANKOTEN, G

机构：

[1] UNIV UPPSALA,DEPT ORGAN CHEM,S-75121 UPPSALA,SWEDEN

[2] UNIV UTRECHT,DEPT MET MEDIATED SYNTH,DEBYE INST,3584 CH UTRECHT,NETHERLANDS

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 17期

关键词：

D O I：

10.1016/0040-4039(95)00426-D

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Asymmetric induction can be achieved in the gamma-selective substitution reaction of allylic substrates (RCH=CH-CH2Y) with n-BuMgI catalyzed by the chiral arenethiolatocopper(I) complex 1b. It was found that the enantiomeric excess of the gamma-substituted product (R'CH(n-Bu)CH=CH2) is influenced by the coordinating ability of the leaving group Y, and e.e.'s of up to 42% (R' = Cy, Y = OAc) have been obtained.

引用

页码：3059 / 3062

页数：4

共 27 条

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[2]

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[3]

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