N-EPSILON-[[2-(TRIMETHYLSILYL)ETHOXY]CARBONYL] DERIVATIVES OF TRI-L-LYSINE AND TETRA-L-LYSINE AS POTENTIAL INTERMEDIATES IN THE BLOCK POLYMER SYNTHESIS OF MACROMOLECULAR DRUG CONJUGATES

被引：7

作者：

ROSOWSKY, A ^{[1
]}

WRIGHT, JE ^{[1
]}

机构：

[1] HARVARD UNIV,SCH MED,DEPT BIOL CHEM & MOLEC PHARMACOL,BOSTON,MA 02115

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1989年 / 54卷 / 23期

关键词：

D O I：

10.1021/jo00284a031

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

引用

页码：5551 / 5558

页数：8

共 27 条

[1]

ALBERT A, 1973, SELECTIVE TOXICITY

[2] USE OF ESTERS OF N-HYDROXYSUCCINIMIDE IN PEPTIDE SYNTHESIS [J].

ANDERSON, GW ;

CALLAHAN, FM ;

ZIMMERMAN, JE .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1964, 86 (09) :1839-+

[3]

ARNOLD LJ, 1985, METHOD ENZYMOL, V112, P270

[4]

ATHERTON E, 1979, TETRAHEDRON LETT, P304

[5] NEW AMINO PROTECTING GROUP REMOVABLE BY REDUCTION - CHEMISTRY OF DITHIASUCCINOYL (DTS) FUNCTION [J].

BARANY, G ;

MERRIFIELD, RB .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1977, 99 (22) :7363-7365

[6] 9-FLUORENYLMETHOXYCARBONYL AMINO-PROTECTING GROUP [J].

CARPINO, LA ;

HAN, GY .

JOURNAL OF ORGANIC CHEMISTRY, 1972, 37 (22) :3404-&

[7]

CHANG CD, 1980, INT J PEPT PROT RES, V15, P59

[8] DIFFERENTIAL TOXICITY OF CARRIER-BOUND METHOTREXATE AGAINST TUMOR BONE-MARROW CELLS INVIVO [J].

CHU, BCF ;

HOWELL, SB .

BIOCHEMICAL PHARMACOLOGY, 1982, 31 (21) :3513-3517

[9] DIFFERENTIAL TOXICITY OF CARRIER-BOUND METHOTREXATE TOWARD HUMAN-LYMPHOCYTES, MARROW AND TUMOR-CELLS [J].

CHU, BCF ;

HOWELL, SB .

BIOCHEMICAL PHARMACOLOGY, 1981, 30 (18) :2545-2552

[10]

DONARUMA LG, 1978, POLYM DRUGS

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