AUTONOMIC FUNCTION IN HYPERTENSION - ARE THERE RACIAL-DIFFERENCES

被引:45
作者
PARMER, RJ [1 ]
CERVENKA, JH [1 ]
STONE, RA [1 ]
OCONNOR, DT [1 ]
机构
[1] UNIV CALIF SAN DIEGO, DEPT MED, SAN DIEGO, CA 92103 USA
关键词
Autonomic function; Baroreceptor reflex; Cold presser test; Hypertension; Nervous system; sympathetic; Phentolamine; Race; α-blockade;
D O I
10.1161/01.CIR.81.4.1305
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Previous biochemical assessment of sympathetic nervous system activity including plasma catecholamines, plasma renin activity, and plasma dopamine-β-hydroxylase levels has suggested racial differences in the contribution of the sympathetic nervous system to the pathogenesis or maintenance of hypertension. We, therefore, performed physiological and pharmacological studies in white and black subjects with essential hypertension and their age-matched normotensive counterparts to assess autonomic and sympathetic nervous system function. One hundred one male subjects (47 white hypertensive, 17 black hypertensive, 22 white normotensive, and 15 black normotensive subjects) were evaluated for baroreceptor reflex sensitivity to low-pressure (amyl nitrite inhalation) and high-pressure (phenylephrine infusion) stimuli; cold pressor test heart rate and blood pressure responses; and blood pressure response to phentolamine α-adrenergic blockade. Hypertensive subjects exhibited an increase in resting heart rate, a decrease in baroreceptor reflex sensitivity, and an exaggerated decline in mean arterial pressure in response to phentolamine. These abnormalities were present to a comparable degree in black and white hypertensive subjects. Cold pressor testing revealed greater increases in heart rate in blacks as compared with whites; however, this racial difference was present regardless of blood pressure status, occurring in black normotensive and black hypertensive subjects to a comparable degree. Cold pressor test blood pressure increments were similar in the four groups. We conclude that both white hypertensive and black hypertensive subjects demonstrate similar abnormalities in autonomic and sympathetic nervous system function including blunting of baroreceptor reflex sensitivity and an increased α-adrenergic receptor participation in blood pressure maintenance. The results do not suggest major racial differences in autonomic pathogenetic mechanisms in hypertension.
引用
收藏
页码:1305 / 1311
页数:7
相关论文
共 59 条
[1]   RACIAL-DIFFERENCES IN BLOOD-PRESSURE AND FOREARM VASCULAR-RESPONSES TO THE COLD FACE STIMULUS [J].
ANDERSON, NB ;
LANE, JD ;
MURANAKA, M ;
WILLIAMS, RB ;
HOUSEWORTH, SJ .
PSYCHOSOMATIC MEDICINE, 1988, 50 (01) :57-63
[2]   RACE, PARENTAL HISTORY OF HYPERTENSION, AND PATTERNS OF CARDIOVASCULAR REACTIVITY IN WOMEN [J].
ANDERSON, NB ;
LANE, JD ;
TAGUCHI, F ;
WILLIAMS, RB ;
HOUSEWORTH, SJ .
PSYCHOPHYSIOLOGY, 1989, 26 (01) :39-47
[3]  
ANDERSON NB, 1989, J HYPERTENS, V7, P161
[4]   RACIAL-DIFFERENCES IN STRESS-INDUCED CARDIOVASCULAR REACTIVITY AND HYPERTENSION - CURRENT STATUS AND SUBSTANTIVE ISSUES [J].
ANDERSON, NB .
PSYCHOLOGICAL BULLETIN, 1989, 105 (01) :89-105
[5]   BIOLOGICAL PATTERNS IN HYPERTENSION BY RACE, SEX, BODY WEIGHT, AND SKIN COLOR [J].
BOYLE, E .
JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1970, 213 (10) :1637-&
[6]   DIMINISHED BAROREFLEX SENSITIVITY IN HIGH BLOOD PRESSURE [J].
BRISTOW, JD ;
HONOUR, AJ ;
PICKERING, GW ;
SLEIGHT, P ;
SMYTH, HS .
CIRCULATION, 1969, 39 (01) :48-+
[7]   RACIAL-DIFFERENCES IN PRESSURE, VOLUME AND RENIN INTERRELATIONSHIPS IN ESSENTIAL HYPERTENSION [J].
CHRYSANT, SG ;
DANISA, K ;
KEM, DC ;
DILLARD, BL ;
SMITH, WJ ;
FROHLICH, ED .
HYPERTENSION, 1979, 1 (02) :136-141
[8]   AGE, RACE, DIAGNOSIS, AND SODIUM EFFECTS ON THE PRESSOR-RESPONSE TO INFUSED NOREPINEPHRINE [J].
DIMSDALE, JE ;
GRAHAM, RM ;
ZIEGLER, MG ;
ZUSMAN, RM ;
BERRY, CC .
HYPERTENSION, 1987, 10 (06) :564-569
[9]  
DRAYER JIM, 1977, CLIN PHARMACOL THER, V22, P286
[10]   MECHANISM OF INCREASED ALPHA ADRENERGIC VASOCONSTRICTION IN HUMAN ESSENTIAL-HYPERTENSION [J].
EGAN, B ;
PANIS, R ;
HINDERLITER, A ;
SCHORK, N ;
JULIUS, S .
JOURNAL OF CLINICAL INVESTIGATION, 1987, 80 (03) :812-817