RELATIONSHIP BETWEEN THE CORTICAL CHOLINE-ACETYLTRANSFERASE CONTENT AND EEG DELTA-POWER

被引：67

作者：

RIEKKINEN, P

SIRVIO, J

RIEKKINEN, P

机构：

[1] Department of Neurology, University of Kuopio, Kuopio

来源：

NEUROSCIENCE RESEARCH | 1990年 / 8卷 / 01期

关键词：

Acetylcholine; Alzheimer's disease; Choline acetyltransferase; Cholinergic deficit; Delta-power; Nucleus basalis;

D O I：

10.1016/0168-0102(90)90052-G

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Destruction of the nucleus basalis abolished normal spectral power only in the frontal cortex, where choline acetyltransferase (ChAT) activity was lower. In lesioned animals, delta-power was increased and alpha-power decreased. The increase in delta-power during immobility correlated with a reduction in ChAT activity. High-voltage spindles occurred more frequently after cholinergic denervation. The results suggest that spectral power and high-voltage spindle analysis might serve as a useful tool for evaluating the efficacy of pharmacological strategies aimed at alleviating the cholinergic deficit. © 1990.

引用

页码：12 / 20

页数：9

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