SECONDARY ACUTE PROMYELOCYTIC LEUKEMIA WITH T(8-21) AND T(9-22) AT ONSET AND LOSS OF THE PHILADELPHIA-CHROMOSOME AT RELAPSE

被引：17

作者：

DALLORSO, S

SESSAREGO, M

GARRE, ML

HAUPT, R

PASINO, M

SANSONE, R

机构：

[1] NATL CANC RES INST,GENET EPIDEMIOL & ONCOGENET SECT,VIALE BENEDETTO XV 10,I-16132 GENOA,ITALY

[2] G GASLINI CHILDRENS HOSP,DIV PEDIAT HEMATOL ONCOL,GENOA,ITALY

[3] UNIV GENOA,CHAIR INTERNAL MED R,I-16126 GENOA,ITALY

来源：

CANCER GENETICS AND CYTOGENETICS | 1990年 / 47卷 / 01期

关键词：

D O I：

10.1016/0165-4608(90)90260-H

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The translocation (8;21) is a typical marker of the M2 subtype of acute nonlymphocytic leukemia, whereas the Philadelphia (Ph) chromosome is predominantly associated with chronic myelogenous leukemia, and seldom with immature acute leukemia, either lymphoblastic or nonlymphoblastic. Furthermore, the association between t(8;21) and a Ph in the same cell is extremely rare. We present a case of secondary acute promyelocytic leukemia with a karyotype 46,XY,t(8;21), t(9;22) at onset. At relapse the patient lost the Ph, while maintaining the t(8;21). This apparently paradoxical pattern of cytogenetic features and evolution is discussed. © 1990.

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页码：41 / 46

页数：6

相关论文

共 15 条

[1] PROPOSALS FOR CLASSIFICATION OF ACUTE LEUKEMIAS [J].

BENNETT, JM ;

CATOVSKY, D ;

DANIEL, MT ;

FLANDRIN, G ;

GALTON, DAG ;

GRALNICK, HR ;

SULTAN, C .

BRITISH JOURNAL OF HAEMATOLOGY, 1976, 33 (04) :451-&

[2] ASSOCIATIONS BETWEEN MORPHOLOGY, KARYOTYPE, AND CLINICAL-FEATURES IN MYELOID LEUKEMIAS [J].

BITTER, MA ;

LEBEAU, MM ;

ROWLEY, JD ;

LARSON, RA ;

GOLOMB, HM ;

VARDIMAN, JW .

HUMAN PATHOLOGY, 1987, 18 (03) :211-225

[3] SECONDARY LEUKEMIA WITH A TRANSLOCATION (8-21) [J].

DAVIES, SV ;

MURRAY, JA ;

BOWSERRILEY, SM .

CANCER GENETICS AND CYTOGENETICS, 1988, 31 (02) :271-274

[4] 8-21 TRANSLOCATION, LOSS OF Y-CHROMOSOME AND PHILADELPHIA CHROMOSOME [J].

FRANCESCONI, D ;

PASQUALI, F .

BRITISH JOURNAL OF HAEMATOLOGY, 1978, 38 (01) :149-150

[5] MYELODYSPLASTIC SYNDROMES - PATHOGENESIS, FUNCTIONAL ABNORMALITIES, AND CLINICAL IMPLICATIONS [J].

JACOBS, A .

JOURNAL OF CLINICAL PATHOLOGY, 1985, 38 (11) :1201-1217

[6] CLINICAL AND CYTOGENETIC CORRELATIONS IN 63 PATIENTS WITH THERAPY-RELATED MYELODYSPLASTIC SYNDROMES AND ACUTE NONLYMPHOCYTIC LEUKEMIA - FURTHER EVIDENCE FOR CHARACTERISTIC ABNORMALITIES OF CHROMOSOME-5 AND CHROMOSOME-7 [J].

LEBEAU, MM ;

ALBAIN, KS ;

LARSON, RA ;

VARDIMAN, JW ;

DAVIS, EM ;

BLOUGH, RR ;

GOLOMB, HM ;

ROWLEY, JD .

JOURNAL OF CLINICAL ONCOLOGY, 1986, 4 (03) :325-345

[7] THERAPY-RELATED ACUTE MYELOID-LEUKEMIA AND MYELODYSPLASTIC SYNDROME - A CLINICAL AND MORPHOLOGIC STUDY OF 65 CASES [J].

MICHELS, SD ;

MCKENNA, RW ;

ARTHUR, DC ;

BRUNNING, RD .

BLOOD, 1985, 65 (06) :1364-1372

[8] MORPHOLOGIC, IMMUNOLOGICAL, AND CYTOGENETIC CHARACTERISTICS OF SECONDARY ACUTE UNCLASSIFIABLE LEUKEMIA IN HODGKINS-DISEASE [J].

ORAZI, A ;

CATTORETTI, G ;

SOZZI, G ;

MIOZZO, M ;

POLLI, N ;

DELIA, D ;

VIVIANI, S ;

NEGRETTI, E ;

DELLAPORTA, G ;

RILKE, F .

TUMORI, 1988, 74 (04) :439-450

[9] ACUTE MYELOGENOUS LEUKEMIA WITH TRANSLOCATION T(8,21) - A CYTOGENETIC STUDY OF 7 CASES [J].

SESSAREGO, M ;

MARENI, C ;

PANARELLO, C ;

GARRE, L ;

FRASSONI, F ;

BOCCACCIO, P ;

AJMAR, F .

CANCER GENETICS AND CYTOGENETICS, 1986, 20 (3-4) :363-368

[10] RISK OF 2ND CANCERS AFTER TREATMENT FOR HODGKINS-DISEASE [J].

TUCKER, MA ;

COLEMAN, CN ;

COX, RS ;

VARGHESE, A ;

ROSENBERG, SA .

NEW ENGLAND JOURNAL OF MEDICINE, 1988, 318 (02) :76-81