THE BIOCHEMICAL BASIS FOR THE DELETERIOUS EFFECTS OF L-CANAVANINE

被引：55

作者：

ROSENTHAL, GA ^{[1
]}

机构：

[1] UNIV KENTUCKY,GRAD CTR TOXICOL,LEXINGTON,KY 40506

来源：

PHYTOCHEMISTRY | 1991年 / 30卷 / 04期

基金：

美国国家科学基金会;

关键词：

CANAVALIA-ENSIFORMIS; LEGUMINOSAE; L-CANAVANINE; NONPROTEIN AMINO ACID; TOXICITY; CANAVANYL PROTEINS; INSECTS;

D O I：

10.1016/S0031-9422(00)95170-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

L-Canavanine, L-2-amino-4-(guanidinooxy)butyric acid, is a potentially toxic analogue of L-arginine. Canavanine-sensitive organisms activate and aminoacylate this non-protein amino acid and thereby create structurally aberrant, canavanine-containing proteins. Incorporation of canavanine into protein can alter the conformation and disrupt the function of the native macromolecule. Production of functionally impaired, canavanyl proteins affects developmental processes and contributes significantly to the expression of canavanine's potent antimetabolic properties in insects.

引用

页码：1055 / 1058

页数：4

共 16 条

[1]

ALLENDE CC, 1964, J BIOL CHEM, V239, P1102

[2]

BLEILER J, 1986, ECOLOGY, V69, P427

[3] L-CANAVANINE, A PARADIGM FOR THE STRUCTURES OF SUBSTITUTED GUANIDINES [J].

BOYAR, A ;

MARSH, RE .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1982, 104 (07) :1995-1998

[4]

CHEN TT, 1978, J BIOL CHEM, V253, P5325

[5]

Greenstein J. P., 1961, CHEM AMINO ACIDS, V1

[6]

Harborne J. B., 1982, Introduction to ecological biochemistry.

[7]

HEGARTY MP, 1968, NATURE, V183, P1116

[8] INDUCED ANTIBACTERIAL PROTEINS IN THE HEMOLYMPH OF PHORMIA-TERRANOVAE (DIPTERA) - PURIFICATION AND POSSIBLE ORIGIN OF ONE PROTEIN [J].

KEPPI, E ;

ZACHARY, D ;

ROBERTSON, M ;

HOFFMANN, D ;

HOFFMANN, JA .

INSECT BIOCHEMISTRY, 1986, 16 (02) :395-402

[9]

MITRA SK, 1967, J BIOL CHEM, V242, P5490

[10]

Rosenthal G. A., 1979, Herbivores: their interaction with secondary plant metabolites, P353

← 1 2 →