GC-MS PROCEDURE FOR THE ANALYSIS OF ZIPEPROL

被引：2

作者：

KINTZ, P ^{[1
]}

FLESCH, F ^{[1
]}

JAEGER, A ^{[1
]}

MANGIN, P ^{[1
]}

机构：

[1] CHRU STRASBOURG,SERV REANIMAT MED,STRASBOURG,FRANCE

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 1993年 / 11卷 / 4-5期

关键词：

ZIPEPROL; DRUG OF ABUSE; GAS CHROMATOGRAPHY MASS SPECTROMETRY; DETERMINATION IN URINE AND PLASMA;

D O I：

10.1016/0731-7085(93)80025-V

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A sensitive and specific quantitative method for the determination of zipeprol, a newly abused antitussive, in human fluids is described. Zipeprol and an internal standard, levallorphan, are isolated by a basic extraction and back-extraction process. The final extract is derivatizated with BSTFA + 1% TMCS and separated on a 12-m HP-1 capillary column. Drugs are detected by selected ion monitoring at m/z 335 and m/z 355 for zipeprol and the internal standard, respectively. The minimum detectable quantities are 0.6 and 0.4 ng ml-1, for zipeprol in plasma and urine, respectively. Relative standard deviations for within-run data are less than 6%.

引用

页码：335 / 338

页数：4