EXTRACELLULAR CA2+ SENSING BY THE OSTEOCLAST

被引:73
作者
ZAIDI, M [1 ]
ALAM, ASMT [1 ]
HUANG, CLH [1 ]
PAZIANAS, M [1 ]
BAX, CMR [1 ]
BAX, BE [1 ]
MOONGA, BS [1 ]
BEVIS, PJR [1 ]
SHANKAR, VS [1 ]
机构
[1] UNIV CAMBRIDGE, PHYSIOL LAB, CAMBRIDGE, ENGLAND
基金
英国医学研究理事会;
关键词
D O I
10.1016/0143-4160(93)90048-B
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
An increasing number of cell types appear to detect changes in the extracellular Ca2+ concentrationand and accordingly modify their function. We review recent evidence for the existence and function of such a mechanism in the osteoclast. Elevated external [Ca2+] in the mM range reduces bone resorption and results in motile changes in the cells. These changes may partly result from elevations of cytosolic [Ca2+] triggered through activation of a surface Ca2+ receptor. Closer analyses of the increases in cytosolic [Ca2+] associated with receptor activation are hindered by the action of this ion both as extracellular agonist and intracellular second messenger. Variations in the peak cytosolic [Ca2+] response to external Ca2+ with changes in cell membrane potential by K+ and valinomycin establish a contribution from extracellular Ca2+. Use of ClO4 , Ni and Cd as surrogate activators in low extracellular [Ca2+] indicate a contribution from Ca2+ release from intracellular stores as well. Such agonists also modify Ca2+ redistribution in other systems, such as skeletal muscle. Thus, we may gain insights into osteoclast extracellular Ca2+ detection and transduction from known features of more well-characterised cell systems.
引用
收藏
页码:271 / 277
页数:7
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