CONTRIBUTION OF THE 5-HYDROXYL GROUP TO THE MUTAGENICITY OF MUCOCHLORIC ACID

被引：32

作者：

LALONDE, RT ^{[1
]}

PERAKYLA, H ^{[1
]}

COOK, GP ^{[1
]}

DENCE, CW ^{[1
]}

机构：

[1] SUNY COLL ENVIRONM SCI & FORESTRY, DEPT PAPER SCI & ENGN, SYRACUSE, NY 13210 USA

来源：

ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY | 1990年 / 9卷 / 06期

关键词：

3,4‐Dichloro‐2(5H)‐furanone; 3,4‐Dichloro‐5‐hydroxy‐2(5H)‐furanone; Direct acting mutagen; Drinking water; Salmonella typhimurium (TA100);

D O I：

10.1002/etc.5620090601

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

The sodium borohydride reduction of 3,4‐dichloro‐5‐hydroxy‐2(5H)‐furanone (mucochloric acid) resulted in the formation of 3,4‐dichloro‐2(5H)‐furanone and 4‐chloro‐2(5H)‐furanone formed in relative amounts of 98 and 2%, respectively. Mucochloric acid and 3,4‐dichloro‐2(5H)‐furanone were assayed together against Salmonella typhimurium (TA100). Mucochloric acid was consistently more mutagenic than 3,4‐dichloro‐2(5H)‐furanone by a factor ranging from 36 to 49 times as established from three determinations of relative mutagenicity. Thus, the hydroxyl group substituted at the 5 position is concluded to have a marked influence on the mutagenicity of a chlorinated 2(5H)‐furanone. Copyright © 1990 SETAC

引用

页码：687 / 691

页数：5

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