ASSOCIATION OF L-TRYPTOPHAN AND AN ILLNESS RESEMBLING EOSINOPHILIC FASCIITIS - CLINICAL AND HISTOPATHOLOGIC FINDINGS IN 4 PATIENTS WITH EOSINOPHILIA MYALGIA SYNDROME

The Centers for Disease Control has recently reported an association between the use of oral L‐tryptophan preparations and a disease marked by severe myalgia, peripheral eosinophilia, and neuromuscular and cutaneous abnormalities. They have labeled the condition eosinophilia‐myalgia syndrome. We report here the clinical and histopathologic findings in 4 patients who developed an illness resembling eosinophilic fasciitis following the initiation of oral L‐tryptophan supplementation. Copyright © 1990 American College of Rheumatology