IDENTIFICATION OF THE DOMINANT CYST ANTIGENS OF TOXOPLASMA-GONDII

被引：23

作者：

WOODISON, G

SMITH, JE

机构：

[1] Department of Pure and Applied Biology, Agricultural Sciences Building, University of Leeds

来源：

PARASITOLOGY | 1990年 / 100卷

关键词：

bradyzoite; cyst antigens; Toxoplasma;

D O I：

10.1017/S0031182000078665

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Brain cysts from three strains of Toxoplasma gondii were purified and analysed by SDS-PAGE and immunoblotting. Western blot analysis revealed the presence of major cyst/bradyzoite antigens at Mr 25000, 36000 and 67000 common to all strains and recognized by many individual sera. There was also evidence of strain variation in cyst antigens with, for example, antigens at Mr88 000, 28 000 and 26 000 unique to the 17025 strain. There was some overlap in the molecular weight of cyst and tachyzoite antigens, but the major tachyzoite surface antigen (P30) could not be detected in brain cysts. © 1990, Cambridge University Press. All rights reserved.

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页码：389 / 392

页数：4

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