PLASMA PROFILES OF ADRENOCORTICOTROPIC HORMONE, CORTISOL, GROWTH-HORMONE AND PROLACTIN IN PATIENTS WITH UNTREATED PARKINSONS-DISEASE

被引：70

作者：

BELLOMO, G ^{[1
]}

SANTAMBROGIO, L ^{[1
]}

FIACCONI, M ^{[1
]}

SCARPONI, AM ^{[1
]}

CIUFFETTI, G ^{[1
]}

机构：

[1] UNIV PERUGIA, SCH MED, DEPT NUCL MED, I-06100 PERUGIA, ITALY

来源：

JOURNAL OF NEUROLOGY | 1991年 / 238卷 / 01期

关键词：

PARKINSONS DISEASE; ADRENOCORTICOTROPIC HORMONE; CORTISOL; GROWTH HORMONE; PROLACTIN;

D O I：

10.1007/BF00319704

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Plasma profiles of prolactin, growth hormone, adrenocorticotropic hormone (ACTH) and cortisol were evaluated in a group of untreated patients with idiopathic Parkinson's disease and a group of healthy age-matched controls. Plasma integrated concentrations of all hormones except prolactin were significantly lower in the patients as compared with the controls; however, prolactin nocturnal peak concentration was significantly elevated in the patients; nocturnal growth hormone levels were significantly reduced in the Parkinson group; ACTH and cortisol plasma concentrations were also consistently lower during most of the day in the patients with Parkinson's disease. These data confirm the presence of a hypothalamic disturbance in patients with idiopathic Parkinson's disease, which can affect pituitary function.

引用

页码：19 / 22

页数：4

共 25 条

[1] FOOD-INDUCED CORTISOL SECRETION IS MEDIATED BY CENTRAL ALPHA-1 ADRENOCEPTOR MODULATION OF PITUITARY ACTH-SECRETION [J].

ALDAMLUJI, S ;

IVESON, T ;

THOMAS, JM ;

PENDLEBURY, DJ ;

REES, LH ;

BESSER, GM .

CLINICAL ENDOCRINOLOGY, 1987, 26 (05) :629-636

[2] ZUR BIOCHEMIE DES PARKINSON-SYNDROMS DES MENSCHEN - EINFLUSS DER MONOAMINOXYDASE-HEMMER-THERAPIE AUF DIE KONZENTRATION DES DOPAMINS, NORADRENALINS UND 5-HYDROXYTRYPTAMINS IM GEHIRN [J].

BERNHEIMER, H ;

HORNYKIEWICZ, O ;

BIRKMAYER, W .

KLINISCHE WOCHENSCHRIFT, 1963, 41 (10) :465-&

[3] NUCLEUS RUBER AND L-DOPA PSYCHOSIS - BIOCHEMICAL POSTMORTEM FINDINGS [J].

BIRKMAYER, W ;

DANIELCZYK, W ;

NEUMAYER, E ;

RIEDERER, P .

JOURNAL OF NEURAL TRANSMISSION, 1974, 35 (02) :93-116

[4]

BLICHERTTOFT M, 1975, ACTA ENDOCRINOL-COP, V78, P5

[5] EFFECT OF APOMORPHINE ON GROWTH-HORMONE RELEASE IN HUMANS [J].

BROWN, WA ;

VANWOERT, MH ;

AMBANI, LM .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1973, 37 (03) :463-465

[6] CORTICOLIBERIN, SOMATOCRININ AND AMINE CONTENTS IN NORMAL AND PARKINSONIAN HUMAN HYPOTHALAMUS [J].

CONTEDEVOLX, B ;

GRINO, M ;

NIEOULLON, A ;

JAVOYAGID, F ;

CASTANAS, E ;

GUILLAUME, V ;

TONON, MC ;

VAUDRY, H ;

OLIVER, C .

NEUROSCIENCE LETTERS, 1985, 56 (02) :217-222

[7]

CONTEDEVOLX B, 1987, PRESSE MED, V16, P566

[8] ERYTHROMELALGIA-LIKE ERUPTION IN PARKINSONIAN-PATIENTS TREATED WITH BROMOCRIPTINE [J].

EISLER, T ;

HALL, RP ;

KALAVAR, KAR ;

CALNE, DB .

NEUROLOGY, 1981, 31 (10) :1368-1370

[9] DIAGNOSIS AND MANAGEMENT OF DIABETIC AUTONOMIC NEUROPATHY [J].

EWING, DJ ;

CLARKE, BF .

BRITISH MEDICAL JOURNAL, 1982, 285 (6346) :916-918

[10] ASSESSMENT OF CARDIOVASCULAR EFFECTS IN DIABETIC AUTONOMIC NEUROPATHY AND PROGNOSTIC IMPLICATIONS [J].

EWING, DJ ;

CAMPBELL, IW ;

CLARKE, BF .

ANNALS OF INTERNAL MEDICINE, 1980, 92 (02) :308-311

← 1 2 3 →