COMPLETE SPONTANEOUS REGRESSION IN METASTATIC RENAL-CELL CARCINOMA - AN UPDATE AND REVIEW

Regression of pulmonary metastases from renal cell carcinoma (RCC) following nephrectomy is well known, although infrequent. Regression of metastases in other organs is extremely rare. However, only 44% of the reported cases in the literature have provided convincing histological proof of metastatic disease prior to the observed regression. Moreover, the majority of cases have occurred following nephrectomy, with or without other therapeutic measures. This paper gives an up-to-date review of 114 cases reported in the literature. The authors' own RCC patients with metastatic spread and showing this clinical phenomenon are also given.