ACTIVATION OF MOUSE RENIN PROMOTER BY CAMP AND C-JUN IN A KIDNEY-DERIVED CELL-LINE

被引：14

作者：

TAMURA, K ^{[1
]}

TANIMOTO, K ^{[1
]}

MURAKAMI, K ^{[1
]}

FUKAMIZU, A ^{[1
]}

机构：

[1] UNIV TSUKUBA,INST APPL BIOCHEM,TSUKUBA,IBARAKI 305,JAPAN

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1993年 / 1172卷 / 03期

关键词：

RENIN PROMOTER; CYCLIC AMP; C-JUN; (MOUSE);

D O I：

10.1016/0167-4781(93)90218-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We demonstrated that the mouse renin promoter from -365 to +16 can mediate the activation by cAMP and c-Jun in a kidney-cell dominant manner. Deletion analysis indicated that the region from -75 to -48 was responsible for the activation by cAMP. Furthermore, the core promoter region from -47 to +16 was sufficient to confer c-Jun inducibility.

引用

页码：306 / 310

页数：5

共 35 条

[1] PHORBOL ESTER INDUCIBLE GENES CONTAIN A COMMON CIS ELEMENT RECOGNIZED BY A TPA-MODULATED TRANS-ACTING FACTOR [J].

ANGEL, P ;

IMAGAWA, M ;

CHIU, R ;

STEIN, B ;

IMBRA, RJ ;

RAHMSDORF, HJ ;

JONAT, C ;

HERRLICH, P ;

KARIN, M .

CELL, 1987, 49 (06) :729-739

[2] CIRCULATING AND TISSUE ANGIOTENSIN SYSTEMS [J].

CAMPBELL, DJ .

JOURNAL OF CLINICAL INVESTIGATION, 1987, 79 (01) :1-6

[3] CELL-SPECIFIC TRANSCRIPTION OF THE PERIPHERIN GENE IN NEURONAL CELL-LINES INVOLVES A CIS-ACTING ELEMENT SURROUNDING THE TATA BOX [J].

DESMARAIS, D ;

FILION, M ;

LAPOINTE, L ;

ROYAL, A .

EMBO JOURNAL, 1992, 11 (08) :2971-2980

[4] REGULATION OF HUMAN RENIN EXPRESSION IN CHORION CELL PRIMARY CULTURES [J].

DUNCAN, KG ;

HAIDAR, MA ;

BAXTER, JD ;

REUDELHUBER, TL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (19) :7588-7592

[5] MOLECULAR-BIOLOGY AND PATHOPHYSIOLOGY OF THE INTRARENAL RENIN-ANGIOTENSIN SYSTEM [J].

DZAU, VJ ;

INGELFINGER, JR .

JOURNAL OF HYPERTENSION, 1989, 7 :S3-S8

[6]

FUKAMIZU A, 1990, J BIOL CHEM, V265, P7576

[7]

FUKAMIZU A, 1991, BIOMED BIOCHIM ACTA, V50, P659

[8]

FUKAMIZU A, 1991, J BIOL REG HOMEOS AG, V5, P112

[9] DISTRIBUTION OF RENIN MESSENGER-RNA AND ITS PROTEIN IN THE DEVELOPING KIDNEY [J].

GOMEZ, RA ;

LYNCH, KR ;

STURGILL, BC ;

ELWOOD, JP ;

CHEVALIER, RL ;

CAREY, RM ;

PEACH, MJ .

AMERICAN JOURNAL OF PHYSIOLOGY, 1989, 257 (05) :F850-F858

[10] MOLECULAR-BIOLOGY OF COMPONENTS OF THE RENIN-ANGIOTENSIN SYSTEM DURING DEVELOPMENT [J].

GOMEZ, RA .

PEDIATRIC NEPHROLOGY, 1990, 4 (04) :421-423

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