THE EFFICACY OF RECOMBINANT HUMAN GRANULOCYTE-COLONY-STIMULATING FACTOR AND RECOMBINANT HUMAN GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR IN PERMITTING THE ADMINISTRATION OF HIGHER DOSES OF CYCLOPHOSPHAMIDE IN A DOXORUBICIN-CYCLOPHOSPHAMIDE COMBINATION - AN NSABP PILOT-STUDY IN PATIENTS WITH METASTATIC OR HIGH-RISK PRIMARY BREAST-CANCER

被引:13
作者
MAMOUNAS, EP
ANDERSON, S
WICKERHAM, DL
CLARK, R
STOLLER, R
HAMM, JT
STEWART, JA
BEAR, HD
GLASS, AG
BORNSTEIN, R
FISHER, B
机构
[1] MICHIGAN STATE UNIV,JACKSON,MI
[2] UNIV LOUISVILLE,LOUISVILLE,KY 40292
[3] UNIV WISCONSIN,MADISON,WI
[4] VIRGINIA COMMONWEALTH UNIV MED COLL VIRGINIA,RICHMOND,VA
[5] KAISER PERMANENTE CTR HLTH RES,PORTLAND,OR
[6] MT SINAI MED CTR,CLEVELAND,OH 44106
来源
AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS | 1994年 / 17卷 / 05期
关键词
COLONY-STIMULATING FACTORS; HIGH-DOSE CHEMOTHERAPY; ADVANCED BREAST CANCER;
D O I
10.1097/00000421-199410000-00002
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Colony-stimulating factors (CSFs) shorten the duration of myelosuppression following chemotherapy and, thus, allow the administration of higher doses. This study evaluates the efficacy of granulocyte macrophage colony-stimulating factor (GM-CSF) and granulocyte colony-stimulating factor (G-CSF) in allowing administration of high-dose cyclophosphamide in combination with doxorubicin. Ninety women with metastatic, locally advanced, or high-risk (greater than or equal to 10 positive nodes) breast cancer and no prior anthracycline treatment were given doxorubicin (60 mg/m(2)) with progressively increased doses of cyclophosphamide (1,200 mg/m(2), 1,800 mg/m(2), and 2,400 mg/m(2)). The first 60 patients received GM-CSF; the remaining 30, G-CSF. The maximum tolerated dose was not reached with 2,400 mg/m(2) of cyclophosphamide. When compared to GM-CSF, G-CSF significantly reduced the duration of granulocytopenia (P < .001). No differences in duration of thrombocytopenia were noted. The results were not sufficiently consistent to indicate a trend toward reduction in rates of febrile neutropenia with one CSF versus the other. However, patients who received G-CSF were hospitalized less frequently than those receiving GM-CSF. With CSFs, high-dose cyclophosphamide in combination with doxorubicin can be safely administered on an outpatient basis. A shorter duration of granulocytopenia resulted from the use of G-CSF than from GM-CSF.
引用
收藏
页码:374 / 381
页数:8
相关论文
共 26 条
[1]   EFFECT OF RECOMBINANT HUMAN GRANULOCYTE MACROPHAGE COLONY-STIMULATING FACTOR ON CHEMOTHERAPY-INDUCED MYELOSUPPRESSION [J].
ANTMAN, KS ;
GRIFFIN, JD ;
ELIAS, A ;
SOCINSKI, MA ;
RYAN, L ;
CANNISTRA, SA ;
OETTE, D ;
WHITLEY, M ;
FREI, E ;
SCHNIPPER, LE .
NEW ENGLAND JOURNAL OF MEDICINE, 1988, 319 (10) :593-598
[2]   EFFECT OF RECOMBINANT HUMAN GRANULOCYTE MACROPHAGE COLONY-STIMULATING FACTOR ON HEMATOPOIETIC RECONSTITUTION AFTER HIGH-DOSE CHEMOTHERAPY AND AUTOLOGOUS BONE-MARROW TRANSPLANTATION [J].
BRANDT, SJ ;
PETERS, WP ;
ATWATER, SK ;
KURTZBERG, J ;
BOROWITZ, MJ ;
JONES, RB ;
SHPALL, EJ ;
BAST, RC ;
GILBERT, CJ ;
OETTE, DH .
NEW ENGLAND JOURNAL OF MEDICINE, 1988, 318 (14) :869-876
[3]   THE USE OF GRANULOCYTE COLONY-STIMULATING FACTOR TO INCREASE THE INTENSITY OF TREATMENT WITH DOXORUBICIN IN PATIENTS WITH ADVANCED BREAST AND OVARIAN-CANCER [J].
BRONCHUD, MH ;
HOWELL, A ;
CROWTHER, D ;
HOPWOOD, P ;
SOUZA, L ;
DEXTER, TM .
BRITISH JOURNAL OF CANCER, 1989, 60 (01) :121-125
[4]   PHASE-I/II STUDY OF RECOMBINANT HUMAN GRANULOCYTE COLONY-STIMULATING FACTOR IN PATIENTS RECEIVING INTENSIVE CHEMOTHERAPY FOR SMALL CELL LUNG-CANCER [J].
BRONCHUD, MH ;
SCARFFE, JH ;
THATCHER, N ;
CROWTHER, D ;
SOUZA, LM ;
ALTON, NK ;
TESTA, NG ;
DEXTER, TM .
BRITISH JOURNAL OF CANCER, 1987, 56 (06) :809-813
[5]  
BUDMAN DR, 1992, P AN M AM SOC CLIN, V11, P51
[6]   REDUCTION BY GRANULOCYTE COLONY-STIMULATING FACTOR OF FEVER AND NEUTROPENIA INDUCED BY CHEMOTHERAPY IN PATIENTS WITH SMALL-CELL LUNG-CANCER [J].
CRAWFORD, J ;
OZER, H ;
STOLLER, R ;
JOHNSON, D ;
LYMAN, G ;
TABBARA, I ;
KRIS, M ;
GROUS, J ;
PICOZZI, V ;
RAUSCH, G ;
SMITH, R ;
GRADISHAR, W ;
YAHANDA, A ;
VINCENT, M ;
STEWART, M ;
GLASPY, J .
NEW ENGLAND JOURNAL OF MEDICINE, 1991, 325 (03) :164-170
[7]   DOSE-RESPONSE IS ALIVE AND WELL [J].
DEVITA, VT .
JOURNAL OF CLINICAL ONCOLOGY, 1986, 4 (08) :1157-1159
[8]   EFFECT OF GRANULOCYTE COLONY-STIMULATING FACTOR ON NEUTROPENIA AND ASSOCIATED MORBIDITY DUE TO CHEMOTHERAPY FOR TRANSITIONAL-CELL CARCINOMA OF THE UROTHELIUM [J].
GABRILOVE, JL ;
JAKUBOWSKI, A ;
SCHER, H ;
STERNBERG, C ;
WONG, G ;
GROUS, J ;
YAGODA, A ;
FAIN, K ;
MOORE, MAS ;
CLARKSON, B ;
OETTGEN, HF ;
ALTON, K ;
WELTE, K ;
SOUZA, L .
NEW ENGLAND JOURNAL OF MEDICINE, 1988, 318 (22) :1414-1422
[9]   DOSE-RESPONSE IN THE TREATMENT OF BREAST-CANCER - A CRITICAL-REVIEW [J].
HENDERSON, IC ;
HAYES, DF ;
GELMAN, R .
JOURNAL OF CLINICAL ONCOLOGY, 1988, 6 (09) :1501-1515
[10]  
HERMANN F, 1989, J CLIN ONCOL, V7, P159